Columbia researchers bioprint seamless 3D skin grafts for burn patients

The science of grafting skin has come a long way from the days of scraping it off one part of a patient’s body and slapping it back on somewhere else to cover a nasty burn or injury. These days grafts are commonly bioprinted like living inkjets using the patient’s cultured cells to seed the growing process, down to the vascularization. The primary shortcoming of these printed grafts is that they can only be produced in flat sheets with open edges. This method “disregard[s] the fully enclosed geometry of human skin,” argue a team of researchers from Columbia University. Instead, they’ve devised a novel means of producing skin in virtually any complex 3D shape they need — from ears and elbows to entire hands printed like a pair of Buffalo Bill’s mittens. 

Alberto Pappalardo and Hasan Erbil Abaci / Columbia University Vagelos College of Physicians and Surgeons

The team published their findings, “Engineering edgeless human skin with enhanced biomechanical properties,” in the January issue of Scientific Advances. They explained how they engineered, “the skin as a fully enclosed 3D tissue that can be shaped after a body part and seamlessly transplanted as a biological clothing.”

“Three-dimensional skin constructs that can be transplanted as ‘biological clothing’ would have many advantages,” Dr. Hasan Erbil Abaci, lead researcher and assistant professor of dermatology at Columbia University, said in a recent press release. “They would dramatically minimize the need for suturing, reduce the length of surgeries, and improve aesthetic outcomes.” 

What’s more, these uniform grafts have shown superior performance, both mechanically and functionally, than their patchwork alternatives. The Columbia team has dubbed the grafts “wearable edgeless skin constructs” (WESCs). Ok, but can you eat them?

The process of making these skin prosthetics isn’t that far off from the existing techniques which result in flat slabs of skin. The transplant site is first scanned with a 3D laser to create a digital facsimile of the structure. That data is worked through a CAD program to generate a hollow wireframe of the appendige and then printed. This serves as the scaffolding on which the patient’s cultured cells will grow. It’s coated with skin fibroblasts and collagen then covered by an outer layer of keratinocytes (which make up the epidermis) and growth medium to feed the cells as they mature. As with making flat sheets, the entire process requires around three weeks for the cells to fully set up and be ready for transplant.

Initial lab tests with mouse models were encouraging. “It was like putting a pair of shorts on the mice,” Abaci said. “The entire surgery took about 10 minutes.” Don’t get too excited, mouse skin is not people skin. It heals differently enough that additional animal studies will be required before we start trying it on humans. Such tests are likely still years away. 

 

Starbucks now lets you pay with Venmo

Starbucks Rewards members can now pay with Venmo. The payment service’s parent company, PayPal, announced the change today, saying customers can use Venmo accounts to load and auto-reload their Starbucks Card funds.

PayPal says you can add your Venmo account in the Starbucks app or the Starbucks Card section of the company’s website. Additionally, you can pay directly from Venmo after adding your account to the coffee chain’s app.

The companies are running a promotion to entice you to try it. Until February 10th, Starbucks Rewards members will get 100 bonus Stars (perks for spending money there) by adding at least $15 from Venmo to their Starbucks Card. Alternatively, spending $15 or more using Venmo as a direct payment in the Starbucks app will also get you the bonus.

This isn’t the coffee chain’s first new partnership as it deals with recent slowdowns. It announced last month it was working with DoorDash to offer 95 percent of its in-store menu items through the delivery service. Unfortunately, it also pounced on the NFT bandwagon, launching an alternative rewards system using digital collectibles.

 

Amazon’s drones have reportedly delivered to fewer houses than there are words in this headline

Amazon’s drone delivery program doesn’t seem to be off to a great start. The Prime Air division was said to be hit hard by recent, widespread layoffs. Now, a new report indicates that Amazon’s drones have made just a handful of deliveries in their first few weeks of operation.

After nearly a decade of working on the program, Amazon said in December that it would start making deliveries by drone in Lockeford, California, and College Station, Texas. However, by the middle of January, as few as seven houses had received Amazon packages by drone, according to The Information: two in California and five in Texas.

The report suggests that Amazon has been hamstrung by the Federal Aviation Administration, which is said to be blocking drones from flying over roads or people unless the company gets permission on a case-by-case basis. Although Amazon had touted its FAA certification, the agency imposed a string of restrictions, which hadn’t been revealed until now. It has largely rejected Amazon’s requests to loosen the limitations.

One of the plans the FAA agreed to, according to the report, was for Amazon employees to check no cars were passing on surrounding roads before drones left its Lockeford delivery facility. That depot is on an industrial block, and the drones need to fly over at least one road before getting to any homes.

Amazon’s drones are far heavier than ones operated by Wing, as well as Walmart’s partners Flytrex and Zipline. Those weigh between 10 and 40 pounds. Amazon’s drone, on the other hand, weighs around 80 pounds and can only carry a five-pound payload. The report suggests the drone’s mass could be causing concern among FAA officials. The agency has given Wing, Flytrex and Zipline permission to fly over roadways — to date, Wing has carried out more than 300,000 deliveries.

One other aspect that doesn’t help Amazon’s prospects is that folks who want to receive deliveries by drone need a backyard where packages can be dropped off — so apartment dwellers need not apply. The drone can only carry a certain size of box and it dumps packages from 12 feet in the air, further limiting the types of products it can transport.

“We meet or exceed all safety standards and have obtained regulatory authorization to conduct commercial drone delivery operations,” Amazon spokesperson Maria Boschetti told The Information. “We welcome the FAA’s rigorous evaluations of our operation, and we’ll continue to champion the significant role that regulators play to ensure all drone companies are achieving the right design, build and operating standards.” Boschetti added that the Prime Air layoffs, which have reportedly slashed the size of the delivery teams at both locations by more than half, have not affected Amazon’s plans for the test sites.

 

Alphabet’s revenues are still growing, but just barely

It’s no secret that the huge tech companies are still making money hand over fist, but there’s also a noticeable slowdown going on. Google’s parent company Alphabet is not immune — the company just reported its earnings results for Q4 of 2022, and just barely grew revenue year over year. The $76 billion the company pulled in during the quarter is up only one percent from Q4 of 2021. 

Google’s ad business is the backbone of the company, and revenue slipped there by about 3.5 percent compared to a year ago. But eight percent growth in the “other” category (which includes products like Google and Nest hardware and revenue from the Play Store) and 32 percent yearly growth in in Google Cloud made up for those ad losses. Overall profits, meanwhile, dropped significantly: Quarterly net income of $13.6 billion is down 34 percent year-over-year.

Of course, the backdrop for all this is that Google announced a few weeks ago that it is laying off about 12,000 employees; that makes up about six percent of the company’s overall workforce. At the time those layoffs were announced, we didn’t yet know what Google’s financials for last quarter looked like, but now we can see that things are slowing down. 

That’s all relatively speaking, though. Net income of $60 billion for 2022 as a whole was down significantly compared to the $76 billion in profit Alphabet made in 2021 — but it’s still far ahead of the $40 billion the company pulled in for 2020. It looks like the big numbers Alphabet posted in 2021 weren’t exactly sustainable, and obviously we don’t yet know what 2023 will bring. But we’ll be tuning into the company’s call with investors, which starts at 4:30PM ET, to see what additional details CEO Sundar Pichai can share about the state of Alphabet in the year to come.

 

Amazon told lawmakers it wouldn’t build warehouse storm shelters

Amazon told lawmakers it wouldn’t build storm shelters in its warehouses after a December 2021 tornado killed six employees at an Illinois location. Although the company changed its severe-weather response strategy after the incident, it essentially told the elected officials that since building storm shelters isn’t required by law, it won’t do that.

The company responded to lawmakers Senator Elizabeth Warren (D-MA) and Representatives Alexandria Ocasio-Cortez (D-NY) and Cori Bush (D-MO), who sent a letter on December 15th, questioning the company’s lack of storm shelters or safe rooms at its warehouses. “Amazon’s apparent unwillingness to invest in a storm shelter or safe room at its Edwardsville facility is made even more concerning by the fact that installing one could be done by Amazon at relatively low cost,” the lawmakers wrote. “This cost is negligible for a company like Amazon, which brought in more than $500 billion in revenue over the 12-month period ending September 30, 2022 and clearly has the resources necessary to protect its workers should it have the will to do so.”

Company vice president of public policy Brian Huseman responded (via CNBC), “Amazon requires that its buildings follow all applicable laws and building codes. We have not identified any jurisdiction in the United States that requires storm shelters or safe rooms for these types of facilities.”

Lawrence Bryant / reuters

Huseman added that Amazon follows Occupational Safety and Health Administration (OSHA) and National Weather Service guidelines and will continue using a “severe weather assembly area” for sheltering in place instead of the requested storm shelters. The six employees and contractors who died at the warehouse tried to protect themselves in a bathroom; the surviving workers took refuge in an assembly area.

OSHA investigated the incident last April and ordered Amazon to review its severe weather policies, but it fell short of penalizing the company for its response. Additionally, Amazon hired a meteorologist, launched an internal center for monitoring severe weather and created emergency cards pointing out evacuation points and assembly areas.

Amazon reportedly began rebuilding the warehouse last June. The families of two of the employees killed there have sued the company for wrongful death.

 

Razer debuts its lightest gaming mouse ever, weighing in at 49 grams

Razer announced its lightest gaming mouse today, the Viper Mini Signature Edition. It only weighs 49g, making it 16 percent lighter than the company’s Viper V2 Pro and one of the most lightweight mice we’ve seen from a large company.

The mouse uses a magnesium alloy exoskeleton with a semi-hollow interior (bearing a slight resemblance to the SteelSeries Aerox 3 Wireless). “We wanted to push beyond the traditional honeycomb design, and this required a material with an outstanding strength-to-weight ratio,” said Razer’s Head of Industrial Design, Charlie Bolton. “After evaluating plastics, carbon fiber and even titanium, we ultimately chose magnesium alloy for its exceptional properties.”

Razer

Razer says the mouse uses its fastest wireless tech and will be among its best-performing wireless mice. It includes the Razer Focus Pro 30K Optical Sensor, Optical Mouse Switches Gen-3 and HyperPolling Wireless with 4000Hz polling rates. Additionally, Razer says the mouse’s battery lasts up to 60 hours and can fully charge via USB-C in less than 90 minutes. It ships with a pre-paired USB dongle.

The $280 mouse will be available exclusively on Razer’s website starting February 11th.

 

Arlo video doorbells and security cameras are up to half off

Folks on the lookout for a new video doorbell or home security camera might be interested in checking out the latest sale on Arlo gear. You can snap up the devices for up to half off at the minute, with the Essential Wire-Free Video Doorbell seeing the biggest drop from $200 to $100.

The doorbell, which you can plug in if you wish, offers a 180-degree wide field view and HD video with HDR. It captures video prior to motion-activated recordings, so you can see what caught the camera’s attention (such as what someone was doing right before ringing the doorbell). You can speak to whoever’s at your door from your phone thanks to two-way audio support. Alternatively, you can respond with quick reply prompts if you’re busy. Arlo says the device is durable too, so it should be able to withstand the elements.

The doorbell should play nicely with other smart home security devices, as it has Amazon Alexa, Google Assistant and Samsung SmartThings support. Those who take out an Arlo Secure plan, meanwhile, will receive notifications when the doorbell detects people, vehicles, and packages.

The sale also includes a wired version of the doorbell, which is 47 percent off at $80. A two-pack of the spotlight camera, which offers 1080p video capture and color night vision without the need for a hub, will run you $160 (31 percent off). Meanwhile, an indoor camera with a privacy shield is $30 off at $70.

Follow @EngadgetDeals on Twitter and subscribe to the Engadget Deals newsletter for the latest tech deals and buying advice.

 

Antartica’s only EV had to be redesigned because of climate change

Most electric vehicles get upgrades to boost performance or range, but Antarctica’s one and only EV has received a tune-up due to the realities of climate change. Venturi has revealed that it upgraded its Venturi Antarctica electric explorer early last year due to warmer conditions on the continent. The original machine was designed to operate in winter temperatures of -58F, but the southern polar region is now comparatively balmy at 14F — and that affected both crews and performance.

The company has added a ventilation system and air intakes to the front of the Antarctica to prevent overheating in the cockpit, while additional intakes keep the power electronics from cooking. Redesigned wheel sprockets were also necessary to maximize the tracked EV’s capabilities. The warmer snow was sticking to the sprockets, creating vibrations as it compacted and hardened. Future upgrades will help restore range lost to changing snow consistency. The Antarctica is built to cover 31 miles, but scientists have been limiting that to 25 miles.

Ars Technicanotes Venturi’s EV has been in use at Belgium’s Princess Elisabeth Antarctica Station since December 2021. It has two modest 80HP motors and just a 52.6kWh battery (plus an optional second pack), but raw power isn’t the point. The design lets station residents perform research without contributing to emissions or polluting a relatively pristine region.

You might not see Venturi make similar climate-related upgrades for a while. However, the refresh shows how global warming can affect transportation in subtle ways. Venturi and other manufacturers may have to design their next explorers on the assumption that Antarctica won’t be as chilly as before.

 

Documents show Meta paid for data scraping despite years of denouncing it

Meta has routinely fought data scrapers, but it also participated in that practice itself — if not necessarily for the same reasons. Bloomberg has obtained legal documents from a Meta lawsuit against a former contractor, Bright Data, indicating that the Facebook owner paid its partner to scrape other websites. Meta spokesperson Andy Stone confirmed the relationship in a discussion with Bloomberg, but said his company used Bright Data to build brand profiles, spot “harmful” sites and catch phishing campaigns, not to target competitors.

Stone added that data scraping could serve “legitimate integrity and commercial purposes” so long as it was done legally and honored sites’ terms of service. Meta terminated its arrangement with Bright Data after the contractor allegedly violated company terms when gathering and selling data from Facebook and Instagram.

Neither Bright Data nor Meta is saying which sites they scraped. Bright Data is countersuing Meta in a bid to keep scraping Facebook and Instagram, arguing that it only collects publicly available information and respects both European Union and US regulations.

Meta has spent years suing individuals and companies for scraping its platforms without permission. In some cases, it has accused companies of masking their activities and accessing sensitive details that require logins. Last year, for instance, Meta sued Octopus last year over a tool that reportedly collected sign-ins and took private information like dates of birth and phone numbers.

However, the Bright Data revelation isn’t a good look for a company that has faced numerous privacy violation accusations, including some related to scrapers. The EU fined Meta €265 million (about $277 million) last fall for allegedly failing to protect Facebook users against scraping that grabbed and exposed private information. This latest case isn’t guaranteed to create further trouble, but certainly won’t help Meta’s defense.

 

Hasselblad X2D 100C: Incredible resolution, beautiful imperfections

After releasing two previous models, Hasselblad seems to have finally nailed the compact medium format camera with the X2D 100C. With a 100-megapixel backside-illuminated sensor that doubles the resolution of the last model, it promises incredible image quality and a stunning design. However, it also has limited autofocus abilities, no video and a large price tag. So is this just a luxury item, or is it good for serious photographers?

My pro photographer friend Nathanael Charpentier wanted to find out. He was interested in seeing if the X2D could help him take more creative photos compared to his current Sony A1 and A9 cameras. At the same time, he was looking to use it in select situations to complement, rather than replace his existing setup.

The X2D is obviously going to work well and take great shots in a controlled studio environment, but Nathanael wanted to test it in more challenging scenarios like live events. As such, he photographed a theatrical group, several professional scenarios, musicians and an evening out – with both the Hasselblad and his Sony A1 for comparison. I also took it myself to test in low light, for landscapes and more.

Body and handling

The X2D is bound to draw comparisons to Fujifilm’s 100-megapixel GFX 100S. On the one hand, Fuji’s model has more advanced technology like eye- and face-detect AI autofocus. However, the Hasselblad offers a better industrial design, handling and build quality.

Physically, they couldn’t be more different. Where the GFX 100S looks like other Fuji mirrorless cameras but larger, the X2D is sleeker and more modern. It has nearly the same design and controls as the X1D II and X1D first introduced in 2017, with a few refinements. That’s great, as the body is both beautiful and practical. There are a few usability quirks, though.

The control layout is sparse compared to the GFX 100S and most other modern mirrorless cameras. It has front and rear dials for primary settings, along with ISO/white balance, mode, power, exposure lock, display and menu buttons. They’re generally responsive and have a high quality feel.

It’s relatively light for its category at 895 grams but still quite heavy. Luckily the big, non-slip grip is nice to hold and makes the X2D comfortable for all-day sessions. Ergonomically, it’s generally easy to use, but I missed having a joystick to move the AF point. That has to be done using either the display or the dials, which can be awkward.

The menu system is equally simple. The main settings are available on one screen, and everything else has its own category, like focus, exposure and general settings. Again, it’s easy to use, but some extra manual controls would help if you need to make adjustments on the fly.

Where the X1D II had a fixed display, the 3.6-inch, has a 2.36-million dot touchscreen. It’s the only way to change many settings, so luckily it’s bright, sharp and reactive. It does tilt up, unlike past models, but only 70 degrees which is insufficient for very low shooting angles. It’s also blocked a bit by the large protruding viewfinder (EVF) when you’re looking straight down.

Steve Dent/Engadget

Speaking of, the OLED EVF is another strong point. It has a sharp 5.76 million dot resolution with a 60 fps refresh rate and a huge 100 percent magnification. It even offers an electronic diopter adjustment for folks who wear glasses, which proved to be effective and kind of cool. Setting it is like taking an eye test, as words come into focus.

On top of the CFexpress Type B slot, the X2D has a built-in 1TB SSD, enough to hold over 3,000 RAW and JPEG shots. It’s easily fast and spacious enough to hold and transfer the enormous images. I never even used the CFexpress slot, except as a backup – but it’s also nice to have a high-speed card slot for rapid transfers.

With 420 shots, battery life is better than on past models, but still on the low end, and that figure is reasonably accurate in our experience. Luckily, it supports PD 3.0 fast charging up to 30W, so you can get a full charge in about 2 hours and run it on AC power in a studio. Still, I’d recommend extra batteries and the optional dual-battery charger, which costs $155 extra.

Steve Dent/Engadget

If you are shooting in a studio, you can use Phocus’s app (on Windows or Mac) for remote triggering and photo organization. It does offer exposure bracketing, but doesn’t have a live view or any way to change settings.

Finally, while the X2D 100C is well made, Hasselblad doesn’t say if it’s weatherproof, So for landscape shooting in bad weather, the GFX 100S might be a better choice as it’s rated by Fujifilm for dust and splash protection.

Nathanael: My first impression was around the handling. I found the ergonomy to be very good. It’s quite heavy, but it has a great grip, so you always have a good hold on it. It was easy to change key settings like ISO, shutter speed and aperture, but moving the autofocus point could be a bit awkward. Once I got used to the controls I was able to shoot pretty quickly.

Performance

With a new processor, the X2D starts up much quicker than before (2 seconds compared to 4 seconds) and is considerably faster in general over the X1D II. Hasselblad also has three new series V lenses (the 38mm f/2.5, 55mm f/2.5 and 90mm f/2.5) that are designed to focus three times faster than past models when used with the X2D’s new hybrid AF system.

Steve Dent/Engadget

Speed isn’t what the camera was built for, but it can manage about 3.3 images per second (in 14-bit mode only), which isn’t bad considering the 215 MB RAW frame size. However, photographers won’t be buying this as a sports camera and most will likely only ever use it in single-shot mode in order to get full 16-bit images.

Where past models had contrast detect autofocus only, the X2D finally has superior hybrid phase detect AF. The implementation, though, isn’t ideal. The single small AF point often wasn’t precise enough for the extremely shallow depth of field. And other than a setting to make the focus point slightly larger, there are no other AF options like area, etc.

Eye and face detection isn’t available either, though Hasselblad has indicated that it’s coming in a future update. Engadget has reached out to the company to find out when that might be happening.

In any case, Nathanael wasn’t too fussed about perfect AF and often preferred manual focus, and that works very well. Like other mirrorless cameras, it has a magnification system that kicks in when you operate the focus ring manually. However, it’s the best implementation I’ve seen – the high sensor resolution allows for a large 100 percent zoom, and it’s very clear on the high-resolution display. At the same time, the improved focus clutch on the new V lenses makes fine focus adjustments quite easy.

Steve Dent/Engadget

Hasselblad’s famous mechanical leaf shutter built into the lenses keeps noise and vibrations to a minimum and allows flash sync up to the maximum 1/2000th speed. As with Fuji’s GFX100s, the electronic shutter isn’t really usable for most moving subjects due to the extreme rolling shutter.

Finally, the X2D is equipped with a new stabilization system developed from scratch by Hasselblad for the large sensor. It allows for a claimed seven stops of blur reduction, compared to six for the GFX 100S. That allowed us to take sharp pictures at shutter speeds as low as a fifth of a second – no mean feat with such an exacting sensor.

Nathanael: I shot almost exclusively in manual focus to start with. It didn’t bother me because there are several tools to help a lot with that. When you turn the focus ring, it really zooms in, and you can clearly see the focus. Later on, I learned all the quirks of the autofocus and figured out how to make it work better, so I started using it more often. At the end, I was mostly taking sharp photos using a mix of manual and autofocus, depending on the situation.

Image Quality

The X2D’s greatest weapon is the new 100 megapixel, backside illuminated sensor – likely the same one used on Fujifilm’s GFX 100S and its own H6D-100C. For reference, the pixel size on the X2D is 3.76 micrometers, the same as Sony’s 61-megapixel A7R V. You can shoot JPEG, 10-bit HEIF or 16-bit RAW photos.

Hasselblad says that dynamic range exceeds 15 stops, which is more than any camera I’ve ever tested. The company also uses what it calls “Natural Color Science” to provide accurate and pleasing hues.

With all that, the X2D delivers the best images I’ve ever seen straight out of a camera. Color rendering is superb, and of course images have more sharpness and detail than nearly every other camera on the market. That’s aided by the new XCD V series lenses, which deliver incredible sharpness all the way to the edge of the frame.

Low-light performance is formidable for such a high-resolution camera as well. Grain is well controlled up to ISO 6400, and while it’s far more noticeable at ISO 12800, picture quality is still excellent. Beyond that, though, grain starts to become noticeable and distracting.

The 16-bit RAW files provide incredible detail and nuance. They can be pulled and stretched in post by a large amount, making them great for pros who do a lot of post-processing. Lightroom worked well for the editing I did, though you’ll need a reasonably powerful computer to handle those enormous file sizes. All that being said, you often don’t need to do much to photos as they look amazing straight out of the camera.

Nathanael: The image quality is really impressive. As soon as I took the first photos and looked at them, I said “wow!” There’s almost no need for post processing. One thing I like is contrast. With the X2D I can take contrasty photos, but they still have tons of detail. And you get incredible dynamic range in low light.

Wrap-up

Steve Dent/Engadget

The X2D is Hasselblad’s best X System camera so far, thanks to improvements across the board but especially with image quality. It now reigns supreme in that area, besting Fujifilm’s rival GFX100S by a good margin.

Yes, the X2D is expensive at $8,200 and the lenses are also sky-high at $3,700 each for the two I tested. That said, it’s not a giant leap over the $6,000 GFX100S and is relatively cheap for a Hasselblad. Plus, it’s designed mostly for pro photographers who would see it as a working tool.

More importantly, how does Nathanael feel about it?

Nathanael: In a way, it’s a return to “real photography,” where you manually control every aspect, even the focus. At the same time, I found it could handle tricky non-studio work. I would only use it in certain situations, like during pre-wedding preparations of the bride: make up, hairstyle, dressing because those are aesthetic moments where you have more time. I’d also use it for photos of the nuptials. However, for critical live work, like the marriage itself, the A1 and A9 would remain my primary cameras.

It’s certainly an outstanding portrait camera, with gobsmacking resolution and image quality. And another thing, when you arrive to shoot with a Hasselblad, it’s noticed by astute clients. It seems like nothing, but it does give extra credibility that you don’t get with other cameras.

So that begs the question: Is it really worth it, or not? Because it’s quite the investment, $8,200 (8,700 euros) for the camera and another $8,000 or so for the lenses. But my feeling is, better equipment lets you take better photos, which helps attract a superior clientele. But that only applies if the camera truly brings something extra to the table, and the X2D really does that.

 

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