Technology - Kalakshar US

An experimental rice-sized implant monitors how drugs affect tumors

Researchers at Brigham and Women’s Hospital in Boston have developed an implant, notably as small as a grain of rice, that can test the effects of drugs on a patient’s brain tumor in real-time during surgery. Currently, monitoring the effects of drugs on a brain cancer patient during surgery is limited to intraoperative brain imaging and tissue sampling after a drug has been administered. The technique known as microdialysis currently stands as one of the more minimally invasive sampling options for testing the impact of drugs on brain tumors, but even that requires an entire catheter to be inserted into the patient’s skull cavity.

During development, researchers from Brigham and Women’s Hospital designed the device specifically to help test treatments in patients with brain cancers or gliomas, a type of tumor that originates in the brain or spinal cord. The device is designed to only remain implanted in a patient for about two to three hours while it delivers microdoses of the respective drug that is under observation. It can observe the impact of up to 20 drugs on the market for cancerous tumors, according to the researchers. Once the device is removed (sometime before the surgery ends), the surrounding tissue is returned to the lab for analysis.

In a statement published Wednesday, Pierpaolo Peruzzi, co-principal investigator and assistant professor in the Department of Neurosurgery at Brigham and Women’s Hospital said that knowing the impact of cancer drugs on these tumors is critical. “We need to be able to understand, early on, which drug works best for any given patient,” he said.

Brigham and Women’s Hospital

During the development process, researchers at the Brigham and Women’s Hospital ran a clinical trial to observe the actual impact of the implant on real patients. The study found that none of the patients in the trial experienced any adverse effects. The researchers were able to collect biological data from the devices, such as what molecular changes happened when each drug was administered. While the study demonstrated that the implant could be easily incorporated into surgical practice, the researchers are still determining how the data it can gather should be used to optimize tumor therapy.

The researchers are now conducting another study that focuses on implanting the device through a minimally invasive procedure 72 hours before their main surgery. Advancements in the cancer treatment space continue to expand, with new iterations of drug cocktails and viruses that can fight cancer cells emerging in the biotech space. Implants like the one developed by the Brigham and Women’s Hospital bring scientists one step closer to better being able to use tools and data to provide more personalized care treatment plans for cancer patients.

This article originally appeared on Engadget at https://www.engadget.com/an-experimental-rice-sized-implant-monitors-how-drugs-affect-tumors-210038580.html?src=rss

Steam will soon show which games support PlayStation controllers

The Steam store will soon tell you if a game supports Sony’s DualSense or DualShock controllers. Valve posted an update for developers this week, announcing that the feature would go live in Steam’s store and desktop app starting in October. Valve hints that more controller-friendly features could be on their way to Steam. “This is the first step toward helping players find games that support the most commonly-used PC video game controllers,” the company wrote.

Developers should now see a new questionnaire in Steamworks, Valve’s game creation tools for its ubiquitous digital storefront. The survey lets devs specify whether their game offers full or partial support for Xbox, DualShock and DualSense controllers. Valve says the filters will also display each PlayStation controller’s usage level, helping gamers learn which gamepads people use the most.

Valve

Valve chalks up the decision to rising numbers of players using PlayStation controllers. It says Sony controller usage has grown from 11 percent of sessions in 2018 to 27 percent today. The company adds that, since 2017, over 87 million Steam users have played at least once using a controller. Among that group, 69 percent have used “some version of Xbox controllers,” while the remainder used “a mix of PlayStation controllers, Switch Pro Controllers, and hundreds of other devices.”

This article originally appeared on Engadget at https://www.engadget.com/steam-will-soon-show-which-games-support-playstation-controllers-213038795.html?src=rss

Google reveals the Pixel 8 design ahead of Apple’s iPhone event

As the consumer tech world shifts its gaze towards Apple’s expected iPhone 15 launch next week, Google appears determined to make sure you don’t forget it has new Pixels in the pipeline. The company posted a sneak peek of the Pixel 8 and Pixel 8 Pro on YouTube, revealing that the phones will be available for pre-order the same day they’re announced: October 4.

Google’s video is little more than a design tease, as it doesn’t showcase or detail any specific features or specs for the handsets that will soon replace the Pixel 7 and 7 Pro. Google also posted a new Google Store landing page today that shows the Pixel 8 / 8 Pro and Pixel Watch 2. 9to5Googlenoticed that the image’s alt text describes the displayed models’ colors as Rose and Porcelain.

The upcoming Pixels have popped up several times lately in what many suspect are intentional leaks to try to cut into Apple’s limelight. Earlier this week, the company posted (and removed) a 360-degree Pixel 8 Pro simulator that allowed visitors to spin the virtual device around and view it from every angle. That “leak” confirmed previously rumored features like a temperature sensor, physical SIM slot and three of its available colors (blue, porcelain and black). The company also published a photo of a person holding a porcelain-colored Pixel 8 Pro on the same day Apple sent out iPhone event invites.

Other leaks have pointed to the higher-end Pixel having a 50-megapixel main camera (that lets in 50 percent more light) and a 64-megapixel ultrawide camera made by Sony. In addition, a 5,000 mAh battery and 27W max charging speed are expected.

Google plans to reveal the devices in an event on October 4 in New York City. “You’re invited to an in-person Made by Google event where we’ll introduce the latest additions to our Pixel portfolio of devices,” reads Engadget’s invitation.

This article originally appeared on Engadget at https://www.engadget.com/google-reveals-the-pixel-8-design-ahead-of-apples-iphone-event-201331081.html?src=rss

Anna Gomez confirmed as FCC commissioner, breaking a 32-month deadlock

For the first time in Joe Biden’s presidency, Democrats will have a majority at the Federal Communications Commission and the ability to undo a wave of Trump-era deregulation in the internet and communications industries. The Senate has confirmed Anna Gomez as the agency’s third Democratic commissioner, bringing an end to a long-standing partisan split on the panel.

Biden nominated Gomez, who is currently a State Department communications policy adviser, to the FCC in May. The president’s previous pick for the FCC’s open chair was Gigi Sohn, who withdrew from consideration in March after enduring attacks from politicians and industry lobbyists. Republicans and certain Democrats such as Sen. Joe Manchin refused to confirm Sohn, who is an advocate for affordable broadband.

However, senators found Gomez a more palatable choice and confirmed her to the panel on Thursday with a 55-43 vote. Gomez worked for the FCC in several positions over a 12-year period before moving into the private sector then onto the State Department earlier this year. She will be the FCC’s first Latina commissioner since Gloria Tristani stepped down in 2001.

Industry bodies and figures such as the Wireless Internet Service Providers Association and former FCC chair and Broadland campaign co-chair Mignon Clyburn have welcomed Gomez’s appointment. “At long last, at this critical time for the US telecommunications and media industries, we have a full roster of FCC commissioners,” Communications Workers of America President Claude Cummings Jr. told Engadget in a statement. “Anna Gomez is a dedicated public servant who is highly qualified to serve on the FCC. We are looking forward to working with her to realize the potential of the bipartisan infrastructure bill to bring affordable internet service to all Americans and to reverse the decline of local news that threatens the foundations of our democracy.“

After Gomez is sworn in, the Biden administration will be able to fulfill some of its major communications policy goals after a years-long partisan deadlock at the FCC. The agency has long had two Democratic and two Republican senators, who have often been unable to agree on policy votes since former chair Ajit Pai left the panel in January 2021.

The FCC is now expected to reverse some telecommunications sector deregulation efforts that the agency carried out under Donald Trump. Those include the potential restoration of Obama-era net neutrality rules, which the agency scrapped in 2017. In recent years, Democratic commissioners have had their hands largely tied, preventing them from taking meaningful action on issues such as internet data caps. However, the agency has still taken action on some fronts, including tackling problems such as robocallers and banning telecom equipment made by Chinese companies such as Huawei and ZTE.

The Democratic commissioners may need to act quickly to carry out agenda items on behalf of the Biden administration, however. Biden has nominated Democratic Commissioner Geoffrey Starks for a second term. His initial term expired last year, but he has remained on the panel in an acting capacity. Unless the Senate re-confirms Starks, the FCC may be back in a deadlock scenario in the not-too-distant future.

This article originally appeared on Engadget at https://www.engadget.com/anna-gomez-confirmed-as-fcc-commissioner-breaking-a-32-month-deadlock-202236997.html?src=rss

BMW’s terrible heated seats subscription didn’t even make it to a second winter

Here’s some news that might shock you: drivers really don’t like paying extra for car features they expect as standard. BMW is one of several automakers that have been nickel and diming customers, including with a monthly subscription for heated seats in certain models and territories. The company has dropped that controversial practice to focus on paid software services — it no longer plans to charge drivers extra to use hardware features that are already in their cars.

Pieter Nota, BMW’s board member for sales and marketing, told Autocar that the brand will train its attention on paid software features such as driving assistance and parking assistance. Nota suggested that’s a more accepted practice, akin to downloading a movie or accessing a paid feature in an app.

However, drivers didn’t take to the $18 per month heated seats subscription in the countries where BMW offered that, er, perk. “We thought that we would provide an extra service to the customer by offering the chance to activate that later, but the user acceptance isn’t that high,” Nota said. “People feel that they paid double — which was actually not true, but perception is reality, I always say. So that was the reason we stopped that.”

It sounds like a classic case of supply and demand. Drivers didn’t want to pay for heated seats (or the likes of heated steering wheels), so BMW stopped doing that. Owners may be heartened to learn that the brand won’t make them pay extra for hardware functions going forward either, which is a step in the right direction. Best of all, BMW has clarified its position on heated seats just before the chillier fall weather starts in the northern hemisphere — the subscription didn’t even make it to a second winter before BMW canned it.

This article originally appeared on Engadget at https://www.engadget.com/bmws-terrible-heated-seats-subscription-didnt-even-make-it-to-a-second-winter-184536200.html?src=rss

GE Aerospace is developing a robotic worm to inspect and repair jet engines

GE Aerospace has demonstrated a worm-like robot that could one day inspect and repair jet engines. The Sensiworm (Soft ElectroNics Skin-Innervated Robotic Worm) is designed to serve as “extra sets of eyes and ears” for service operators as they examine the insides of aircraft. GE says the soft robot can minimize downtime and perform less invasive inspections and, in the future, make repairs itself.

The company compares the Sensiworm’s role in aerospace engineering and repairs to how soft robotics have allowed for minimally intrusive patient surgeries. “These technologies are enabling less invasive inspection and repair of jet engines on the wing to reduce downtime,” the company wrote. GE says the worm-like machine could give operators “virtually unfettered access” to inspect engines without disassembling them.

GE Aerospace

Resembling an inchworm, the Sensiworm (remote-controlled by operators) can crawl across various engine parts, including rotating wind turbine blades. It can sense and avoid obstacles automatically, reach places where gravity may stop other tools (thanks to its suction-cup feet) and measure the thickness of thermal barrier coatings. GE says it can even sniff out gas leaks. “With their soft, compliant design, they could inspect every inch of a jet engine, transmitting live video and real-time data about the condition of parts that operators typically check,” the company wrote.

GE Aerospace developed the robo-worm through SEMI Flex Tech, a US Army-funded public / private coalition focused on advancing flexible electronics. GE hasn’t mentioned how far along the worm is in its development or when we can expect deployment in the field. Engadget asked a company spokesperson to clarify, and we will update the article if they respond.

The video below shows the Sensiworm in action (complete with its own theme music).

This article originally appeared on Engadget at https://www.engadget.com/ge-aerospace-is-developing-a-robotic-worm-to-inspect-and-repair-jet-engines-191512246.html?src=rss

Snapchat is trying to make it harder for teens to connect with strangers

Snapchat is adding new features meant to discourage teens from interacting with strangers on its app. The changes come after years of scrutiny on the app as lawmakers and other officials have questioned Snap’s ability to keep teens safe.

As with previous updates, the new restrictions primarily affect the accounts of 13- to 17-year-olds on the app. Last year, the company began limiting the visibility of teens’ accounts in its “Quick Add” recommendations to limit strangers’ ability to find young people in the app. Now, the company says it will make teens even harder to find in search and recommendations by increasing the number of mutual friends users must have in order to appear in search and suggested accounts.

And, in cases when teens are able to connect with people with whom they don’t share many mutual friends, Snap will surface warnings encouraging users to only interact with people they know. The warning will be accompanied by an option to block or report the user in question.

The company is also introducing a new strike system for accounts that share “age-inappropriate content” in public-facing parts of the app, like Stories and Spotlight. Under the new system, the app will remove posts that it deems age-inappropriate and dole out a strike to the offending account. Users who rack up too many strikes over a set period of time will have their accounts permanently disabled, according to the company.

Snap has also published a new section of its website aimed at parents who have potential concerns about their teens’ use of Snapchat. The site offers several explainers about the app, including guides on how to use its parental control features.

This article originally appeared on Engadget at https://www.engadget.com/snapchat-is-trying-to-make-it-harder-for-teens-to-connect-with-strangers-190015266.html?src=rss

You can now search Threads for signs of life

Thank the social media makers. Meta’s Threads is officially rolling out a keyword search feature in the United States, alongside many other countries including India, Canada, Mexico and the UK. This has been one of the most asked-for tools since the platform launched in July. Keyword search appeared last week as a beta in New Zealand and Australia, and it looks that beta was a success given today’s announcement.

Keyword search, known as hashtags or text search in some circles, is vital for connecting with communities and for following real-time events. Oddly, Threads is the first major Twitter/X competitor to integrate the feature, which could spell even more trouble for Elon Musk’s beleaguered social media site.

A Meta representative told Engadget that keyword search is being integrated into both mobile apps and the recently-launched web app, so you’ll have your pick of where to search for Star Trek fans or whatever it is you’re into. The company said it’s working on bringing the search function to other languages and countries in the near future. Before this update, you could only use search to look for active Threads accounts.

Meta has been aggressive about adding features to Threads, which is good because the app had an extremely strong start but has fizzled since the initial launch. Maybe this latest update will entice users to return to the service.

This article originally appeared on Engadget at https://www.engadget.com/you-can-now-search-threads-for-signs-of-life-193007064.html?src=rss

Biometric implant monitors transplant patients for organ rejection

Researchers at Northwestern University developed a bioelectric implant that can detect temperature fluctuations that typically happen right before a body rejects an organ transplant. The sensor is smaller than a fingernail, and a mere 220 micrometers thick.

This new sensor technology is thin enough to sit directly on a kidney’s fibrous layer — called the renal capsule — which surrounds and protects the organ. The device works by continuously monitoring changes to blood flow and temperature. The built-in thermometer can sense increases as minuscule as 0.004 degrees Celsius. Once an irregularity is detected, the sensor, which contains a micro coin cell battery for power, uses Bluetooth to alert a patient or physician via a smartphone or tablet. Any increase typically signals inflammation which is a potential sign of transplant rejection.

After any surgery that involves an organ transplant, the risk of rejection is high. The sensor was developed specifically for kidney transplants but it could also work for other organs, including the liver and lungs. Kidney transplants in the US are on the rise and are usually recommended for people who will not be able to live without dialysis. The American Kidney Fund cites that an acute rejection of a kidney transplant one month after surgery happens in about five to twenty percent of patients that go under.

That’s why it is critical to detect transplant rejection, which occurs when your body’s immune system treats the new organ like a foreign object and attacks it. If a healthcare provider detects signs of rejection early enough, medical intervention can preserve the new organ in the new host. Northwestern researchers said that the device detected warning signs of organ rejection three weeks earlier than current monitoring methods. The current “gold standard” for detecting rejection is a biopsy, where a tissue sample is extracted from the transplanted organ and then analyzed in a lab. However, biopsies are invasive and can cause bleeding and increase the risk for infection.

Northwestern University

Despite developing an innovative first-of-its-kind product, researchers at Northwestern University still have a long way to go. It still needs to be tested on humans in a clinical setting before it can make any impact in the surgical market. Northwestern’s John A. Rogers, a bioelectronics expert who led the device development, said in a statement that his team is now evaluating ways to recharge the coin cell battery so that it can last a lifetime.

This article originally appeared on Engadget at https://www.engadget.com/biometric-implant-monitors-transplant-patients-for-organ-rejection-180045215.html?src=rss

What to expect at Apple’s ‘Wonderlust’ iPhone 15 event

Apple’s latest fall iPhone event — “Wonderlust” — is nearly here. Four new iPhones and a couple of Apple Watch models are expected to take center stage when the company showcases its latest products. USB-C should be in the spotlight as Apple changes its charging ports in response to new EU regulations. Although nothing is set in stone until Tim Cook takes the stage on Tuesday, we’ve gathered the most probable leaks and rumors ahead of Apple’s September 12 event.

iPhone 15 and iPhone 15 Pro

No matter what else Tim Cook and company reveal, new iPhones are practically guaranteed to dominate the day’s headlines. We can expect a high-end iPhone 15 Pro and iPhone 15 Pro Max, along with a standard iPhone 15 and iPhone 15 Plus. There was an earlier report that Apple may rebrand the Pro Max model as “iPhone 15 Ultra” this year, but it isn’t clear if that’s still on the table.

First, screen sizes will likely stand pat. That means 6.1-inch displays for the iPhone 15 and 15 Pro and 6.7-inch screens for the iPhone 15 Plus and iPhone 15 Pro Max (or “Ultra”). ProMotion, Apple’s branding for 120Hz variable refresh rate displays, will almost certainly remain exclusive to the top-tier models.

Cherlynn Low / Engadget

A change many foresee is Lightning cables becoming obsolete. Over a decade has passed since switching from 30-pin connectors to Lightning, and European regulations are forcing Apple to swap ports again — this time to USB-C. “Obviously, we’ll have to comply” with the EU’s requirements, Apple VP Greg Joswiak confirmed in an interview with the WSJ last year. Although Apple could wait for next year’s iPhone launch to make the EU’s deadline, leaks and well-sourced insiders indicate almost unanimously that this year’s iPhone 15 will be the one to kick off the USB-C iPhone era.

However, connected Apple analyst Ming-Chi Kuo predicts only the higher-end iPhone models will see faster USB-C data transfer speeds. Kuo believes only the two pro models will support “at least USB 3.2 or Thunderbolt 3” high-speed wired connections, while the two standard models (iPhone 15 / 15 Plus) would use slower USB 2.0 speeds, the same as Lightning. At least some new models could also support faster (35W) charging speeds, although (predictably, some might say) you could need a proprietary Apple-made adapter to power up at those rates.

Dynamic Island, the display cutout that Apple launched on the iPhone 14 Pro / Pro Max, is expected to carry over to all four models in 2023. A replacement for the “notch” on older full-screen iPhones, Dynamic Island is a floating black pill-shaped section just below the top of the screen. It not only masks the phone’s front camera and Face ID sensor, but it can also flash alerts, animations and shortcuts for tasks like driving directions, timers or music. Apple design VP Alan Dye tidily summarized that Dynamic Island can “display alerts, notifications, and ongoing operations in real-time without seeing the boundary between hardware and software.”

Cherlynn Low / Engadget

Stainless steel may go the way of the Lightning port, as the iPhone 15 Pro and Pro Max are rumored to switch to titanium frames. The material upgrade could make the new pro lineup “stronger, lighter and more premium,” as Bloomberg’s Mark Gurman described in July. He said the titanium used in high-end Apple Watch models was “a test for bringing that material to its highest-volume device.” Although the phones are expected to keep the same frosted glass back, their corners could be more rounded than in previous models. In addition, Apple may drop the lineup’s gold hue for a “titan gray” colorway.

Thinner bezels are expected to accompany the pro series’ titanium frame. Apple is reportedly developing the iPhone 15 Pro / Pro Max displays with a process called low-injection pressure over-molding, or “LIPO.” First used in Apple Watch Series 7 manufacturing, Gurman reported that the technology could reduce the pro series’ bezels to 1.5 mm, down from the 2.2 mm ones found in current models.

The iPhone 15 Pro series could also have an Action Button like on the Apple Watch Ultra. The customizable toggle would replace the mute switch on the upper-left side of the pro-tier iPhones. Possible uses for the Action Button (based on code uncovered in iOS 17) include launching the camera, lighting the phone’s flashlight, activating Focus, opening accessibility features or standing pat with the standard mute function. Sources indicated Apple initially wanted to swap in haptic solid-state ones for the iPhone’s physical volume and power buttons, but the company reportedly canceled the feature after encountering “unresolved technical issues before mass production.” So expect standard volume and power / sleep buttons.

Apple

The most likely camera upgrade is a new periscope lens exclusive to the iPhone 15 Pro Max (or Ultra). It would use a prism to bend or fold light captured by the sensor, leading to an optical zoom of 5x to 6x without making the phone beefier. The iPhone 14 Pro series supports up to 3x optical zoom.

One of the surest bets about a new flagship iPhone’s features is a faster, next-generation chip. The iPhone 15 Pro and Pro Max are rumored to use a 3nm chip, likely called the A17 Bionic. It would provide performance boosts (and maybe longer battery life). Meanwhile, the iPhone 15 / 15 Plus pair is rumored to repeat what the company did in 2022: recycling last year’s high-end chip. That means the iPhone 15 / 15 Plus would use the A16 Bionic, found in the iPhone 14 Pro.

If recent years are any indication, the new iPhones would be available for pre-order the Friday after the event, with shipments and general availability kicking off a week later. Although this year’s models may be more expensive.

Apple Watch Series 9 and Apple Watch Ultra

This could be a minor year for Apple Watch updates. The primary hardware change in the Apple Watch Series 9 is rumored to be an S9 chip, marking the product’s first real processor upgrade since 2020. Gurman reported that the S9 will be based on the A15 chip that debuted in Apple’s iPhone 13 (2021) lineup. The S9’s full details aren’t known, but it’s rumored to move from a 7nm manufacturing process to a denser and more efficient 5nm or 4nm one. Expect performance boosts and (perhaps) longer battery life.

Reports suggest the new Apple Watch will otherwise be a largely ho-hum update, with Gurman saying this year’s model won’t offer any significant design changes or new features. A pink color option and Bluetooth 5.3 support are possible changes for the new model. Regardless, watchOS 10 — arguably the biggest software update in the wearable’s history — will likely stand as the biggest advancement for the Apple Watch in 2023.

Cherlynn Low / Engadget

As for the Apple Watch Ultra, it’s also expected to receive an incremental 2nd-generation update. In addition to the S9 chip, a new Apple Watch Ultra could add a black titanium case. The current model ships in a “natural” color, expected to return alongside the darker option.

AirPods

Ken Pillonel

You probably want to keep your AirPods expectations in check, as Apple’s march away from Lightning and towards USB-C will likely be the only headphone upgrades at this event. The company will reportedly launch “new” versions of the current AirPods models, with charging cases that use USB-C instead of Lightning serving as the only difference.

Rumored changes to the AirPods lineup down the road include body-temperature sensors, accessibility features for people with hearing disabilities and a potential price drop for the entry-level model. But we won’t likely see any of that on Tuesday.

Software

Apple

You can expect the event to bring more details about Apple’s first big 2023 software updates: iOS 17, watchOS 10 and (possibly) iPadOS 17. Apple announced the operating systems at WWDC 2023, and their final versions should become available to the public sometime between the event and the iPhone 15 launch. Following recent years’ patterns, macOS Sonoma will likely launch in October — with iPadOS 17 joining if it isn’t included alongside iOS 17. A potential October event could consist of new iMac, MacBook Air and 13-inch MacBook Pro models running the M3 chip.

iOS 17 includes a new StandBy mode, voicemail transcriptions, FaceTime video voicemails, contact posters, NameDrop and new in-line predictive text suggestions (among other additions). Meanwhile, watchOS 10 is arguably the platform’s most significant update since the wearable’s 2015 launch. The new software changes the Apple Watch’s fundamental control scheme: The side button now activates Control Center (instead of recent apps or the dock), and twisting the watch’s Digital Crown from the watch face scrolls through a customizable stack of glanceable widgets.

You can read more about the upcoming software in Engadget’s previews of iOS 17, iPadOS 17 and watchOS 10 coverage.

This article originally appeared on Engadget at https://www.engadget.com/what-to-expect-at-apples-wonderlust-iphone-15-event-181545715.html?src=rss