Category: Technology

The Environmental Protection Agency has scrapped a plan to phase out mammal testing for studying chemical toxicity, Science reports. In 2019, the regulatory agency vowed to completely phase out animal testing for toxicology studies by 2035 in favor of non-animal “test subjects” programmed into computer models.

The call to challenge the status quo was controversial from the start — it not only was going to impact thousands of studies and experiments, but many scientists argued that computer models were nowhere near ready to replace animals as test subjects. In a letter written by a group of public health officials, the experts urged the EPA’s head Michael Regan to reconsider the ban because computational models, in their opinion, were “not yet developed to the point” where they could be relied on for risk assessments.

In order for the new ban to have taken effect, the EPA said there needed to be “scientific confidence” that non-animal models could soundly replace critters like mice and rabbits in labs. Despite the 2035 deadline being put on ice, however, an EPA spokesperson told Science that it would still explore alternatives to animal testing.

The ambitious plan is not entirely a lost cause, though. While the EPA hasn’t made any official statements about how it plans to work toward its original goal, now without a deadline, some studies have shown promise that computational models might effectively reflect the toxicology of certain chemicals during testing. In some instances, these studies suggest, they can even outperform lab rats.

3D developments like technical organoids are also popping up on the research front by way of stem cells that allow duped livers to be tested and evaluated during research as a human liver would. Labs are currently working on ways to more effectively develop realistic organs using 3D printers. But it might be a while before 3D printing can consistently be used to assist biologists and pharmacologists for research and drug testing.

This article originally appeared on Engadget at https://www.engadget.com/epa-scraps-plan-that-would-have-had-it-ban-mammal-testing-in-favor-of-computer-models-204540435.html?src=rss 

NASA’s X-59 Quesst supersonic commercial jet, which is being developed by Lockheed Martin, will have its flight test livestreamed as a demonstration of how quiet it can be in the air. The $247.5 million Quesst, whose name is short for Quiet SuperSonic Tech, will be shown on the livestream dramatically emerging from Lockheed Martin’s Skunk Works facility in Palmdale, California. NASA has been on a mission since 2018 to prove that its X-59 can fly over cities without producing noise pollution, or sonic booms. This test flight marks an important milestone in the six-year-old project.

The first flight will be streamed on January 12 at 4pm ET on YouTube, as well as the NASA app and the NASA+ streaming service.

The space agency said it will survey people about the noises they hear from the jet during the first flight. It did not specify how it would find these people, or many people it would poll. The data collected will be sent to regulators and used to help propose new rules that limit the use of supersonic jets. The US federal government has blocked all civilian supersonic jets from flying over land for over five decades.

When NASA first announced its quiet supersonic technology project in 2018, administrator Jim Bridenstine said, “This aircraft has the potential to transform aviation in the United States.” While the jet was supposed to first take flight in 2021, the debut today still marks a major milestone in the QueSST mission. By 2027, NASA expects to have more definitive results about how effective the new aircraft technology is at reducing flight noise.

If new laws are eventually passed that permit supersonic jet aircrafts to fly in close proximity to land, high-speed commercial flights could become a reality. Once NASA and Lockheed Martin finalize development of the aircraft, the agency said it will conduct safety evaluations for about nine months. After enough evidence is shared to prove that the Quesst aircraft can be flown safely, NASA plans to expand its flight tests to cities across the US and collect more information about the noise it produces through additional surveys.

This article originally appeared on Engadget at https://www.engadget.com/nasas-new-x-59-plane-could-hit-supersonic-speeds-with-minimal-sonic-boom-210037676.html?src=rss 

Welcome back to our weekly gaming news roundup. 

January is a magical time in the video game industry. We’ve just closed out 12 months of marketing hype and shifting production timelines, and the year ahead is filled with the promises of new titles and fresh hardware. During this special month, we can look at the 2024 release calendar with excitement and optimism, before the delays start rolling in. So, let’s get to it — these hearts aren’t going to break themselves.

This week’s stories

Arcane season 2 teaser

You watched Arcane, right? The Netflix series set in the League of Legends universe debuted in late 2021 and it was an instant sensation, starring fan-favorite characters like Jinx, Vi and Caitlyn. The next season is set to come out in November and Riot dropped a one-minute teaser for it last Friday. The trailer has Singed experimenting on himself in a dreary laboratory, while a creature that looks like Warwick hangs above, connected to tubes and IVs. It’s gonna get dark, kids.

If you haven’t watched season one of Arcane, do that now.

This kid beat Tetris

I guess we can all stop playing Tetris. 13-year-old Willis Gibson became the first person to reach the killscreen in the classic NES version of Tetris, 34 years after the game’s debut. Gibson caught the moment on camera and honestly, it gives me goosebumps every time I watch it. The competitive Tetris scene has been steadily growing over the past few years, and players are using a new input technique called rolling that allows them to move pieces faster than ever. If you’re into this kind of thing, I recommend watching Classic Tetris Monthly on Twitch or YouTube.

Promises, promises

Before we get back into all the award shows and livestreams and media events this year, let’s take a look at the video game promises heading into 2024.

There’s nothing official yet, but it looks like Nintendo is preparing to release the Switch 2 in 2024, seven years after the launch of the original Switch, and right in the middle of the PS5 and Xbox Series X console cycle. According to early reports, the Switch 2 will be an iterative hardware update with slightly more processing power and support for DLSS and raytracing. The big news is that Nintendo has finally joined us in the 21st century, and players should be able to transfer their Switch games to the new console without any roadblocks.

Outside of the new Switch, 2024 is all about games. We know how this goes, right — in video games, a release date is really just the first step before a delay, so whatever you’re into, prepare for heartbreak over the next 12 months.

There are two games I’m confident will actually hit the market on their release dates in 2024, and that’s only because they’ve been in development for years and delayed multiple times already. Ubisoft’s open-world pirate simulator Skull and Bones is due out on February 16 for PS5, Xbox and PC, and Final Fantasy VII Rebirth will hit PS5 on February 29. Rebirth looks legit, while Skull and Bones … doesn’t.

Overall, we have a healthy lineup of titles to get excited about in 2024. First, on the mainstream front: 

January 18: Prince of Persia: The Lost Crown | Ubisoft Montpellier

January 19: The Last of Us Part 2 Remastered | Naughty Dog

January 26: Tekken 8 | Bandai Namco Studios, Arika

February 2: Suicide Squad: Kill the Justice League | Rocksteady Studios

February 2: Persona 3 Reload | P-Studio

February 16: Skull and Bones | Ubisoft

February 29: Final Fantasy VII Rebirth | Square Enix

March 22: Dragon’s Dogma 2 | Capcom

March 22: Princess Peach: Showtime! | Nintendo

March 22: Rise of the Ronin | Team Ninja

2024: Silent Hill 2 remake | Bloober Team

2024: Star Wars Outlaws | Massive Entertainment

2024: Avowed | Obsidian Entertainment

2024: Senua’s Saga: Hellblade 2 | Ninja Theory

2024: Concord | Firewalk Studios

2024: Paper Mario: The Thousand-Year Door | Nintendo

This isn’t a comprehensive list for the year in AAA gaming, but it’s a solid start. 

And then there are the games I’m personally looking forward to in 2024. Most of these still have vague release windows — it’s as if the developers didn’t want to give a timeframe at all, so they just whispered 2024 to their marketing teams and hoped no one would notice. But I did. I always do. I’m always watching.

Here are the games on my underground radar this year (again, this isn’t an exhaustive list because there are so many fantastic games nowadays, but these ones spring to mind):

January 16: Home Safety Hotline | Night Signal Entertainment

August 20: Black Myth: Wukong | Game Science

2024: Skate Story | Sam Eng

2024: Lorelei and the Laser Eyes | Simogo

2024: Baby Steps | Gabe Cuzzillo, Maxi Boch, Bennett Foddy

2024: The Plucky Squire | All Possible Futures

2024: Mewgenics | Edmund McMillen, Tyler Glaiel

2024: 33 Immortals | Thunder Lotus

2024: Thank Goodness You’re Here! | Coal Supper

2024: Despelote | Julián Cordero, Sebastian Valbuena

2024: Time Flies | Playables, Raphaël Munoz, Michael Frei

2024: Cryptmaster | Paul Hart, Lee Williams, Akupara Games

2024: Hades 2 | Supergiant Games

2024: Hyper Light Breaker | Heart Machine

When any of these titles is inevitably delayed, we can all gather right here and have a good cry. Let us know in the comments what you’re looking forward to this year and why it’s Hollow Knight: Silksong.

Now Playing

I’ve been sticking with local co-op games during these chilly winter months, and now I’ve moved on to Baldur’s Gate 3. I know, I know, everyone is already telling you to play it, but this pitch is strictly for the splitscreen crowd — Baldur’s Gate 3 is a joy to play alongside a loved one, as long as your cleric actually remembers to heal your party every now and then. You know who you are.

This article originally appeared on Engadget at https://www.engadget.com/nintendo-switch-2-and-games-to-get-excited-about-in-2024–this-weeks-gaming-news-211257742.html?src=rss 

New year, new… desktop setup? If you’re looking for ways to spruce up your desk space without breaking the bank, it’s worth taking a peek at a Logitech sale on Amazon that includes discounts on mice, webcams and other accessories. Most of us could do with a webcam upgrade (I know I could given the low-res one built into my laptop), and Logitech’s Bio 300 may fit the bill. It’s a Full HD 1080p webcam that’s on sale for $44.85. That’s a 25 percent discount, or just over $15 off the usual price of $60.

The Bio 300 has a privacy shutter, 70-degree field of view, auto-light correction function, LED activity light, built-in mono noise reducing microphone and USB-C connector. You’ll be able to use the Logi Tune app to adjust color and image quality. Those concerned with sustainability may be pleased to learn it’s made with 48 percent post-consumer recycled plastic too. The slightly speckled plastics help give the webcam a fresh look.

One other product that caught our eye in the sale is the Pebble 2 M350s mouse. That’s on sale for $25, which marks a record low. The wireless mouse usually costs $30. The Pebble 2 is available in black, white or a fetching rose to match the aforementioned webcam. It too is built with at least 58 percent certified post-consumer recycled plastic.

This low-profile mouse has quiet clicking sounds and is highly portable, making it a good fit for those who move around with their laptops. It supports Bluetooth 5.1 and the Logitech Bolt receiver, and it’s able to pair with up to three devices (you can switch between them using a button on the base). The middle button is customizable and supports shortcuts. Logitech says the Pebble 2 M350s will run for up to two years before you have to change the battery.

Follow @EngadgetDeals on Twitter and subscribe to the Engadget Deals newsletter for the latest tech deals and buying advice.

This article originally appeared on Engadget at https://www.engadget.com/logitech-mice-webcams-and-accessories-are-up-to-25-percent-off-at-amazon-201429217.html?src=rss 

Another lawmaker is pushing the Securities and Exchange Commission for more information about its security practices following the hack of its verified account on X. In a new letter to the agency’s Inspector general, Senator Ron Wyden, called for an investigation into “the SEC’s apparent failure to follow cybersecurity best practices.”

The letter, which was first reported by Axios, comes days after the SEC’s official X account was taken over in order to post a tweet claiming that spot bitcoin ETFs had been approved by the regulator. The rogue post temporarily juiced the price of bitcoin and forced SEC chair Gary Gensler to chime in from his X account that the approval had not, in fact, happened. (The SEC did approve 11 spot bitcoin ETFs a day later, with Gensler saying in a statement that “bitcoin is primarily a speculative, volatile asset that’s also used for illicit activity.”)

The incident has raised a number of questions about the SEC’s security practices after officials at X said the financial regulator had not been using multi-factor authentication to secure its account. In the letter, Wyden, who chairs the Senate’s finance committee, said it would be “inexcusable” for the agency to not use additional layers of security to lock down its social media accounts.

“Given the obvious potential for market manipulation, if X’s statement is correct, the SEC’s social media accounts should have been secured using industry best practices,” Wyden wrote. “Not only should the agency have enabled MFA, but it should have secured its accounts with phishing-resistant hardware tokens, commonly known as security keys, which are the gold standard for account cybersecurity. The SEC’s failure to follow cybersecurity best practices is inexcusable, particularly given the agency’s new requirements for cybersecurity disclosure”

Wyden isn’t the only lawmaker who has pushed the SEC for more details about the hack. Senators J. D. Vance and Thom Tillis sent a letter of their own, addressed to Gensler, immediately following the incident. They asked for a briefing about the agency’s security policies and investigation into the hack by January 23.

The SEC didn’t immediately respond to a request for comment. The agency said in an earlier statement that it was working with the FBI and the Inspector General to investigate the matter.

This article originally appeared on Engadget at https://www.engadget.com/senators-want-to-know-why-the-secs-x-account-wasnt-secured-with-mfa-203614701.html?src=rss 

Bandai Namco’s Sand Land finally has a release date of April 26. This is a video game adaptation of a classic manga by artist Akira Toriyama. That’s the same Akira Toriyama who created Dragon Ball, and also created the character designs for Chrono Trigger and many entries in the Dragon Quest series.

Sand Land is a manga dating back to the mystical year of 2000 and it follows the adventures of the literal Devil’s son, Beelzebub, as he explores a desert world accompanied by a human sheriff and a demon thief. Interestingly, the game seems like a beat-for-beat recreation of the anime, only in the form of a fast-paced action RPG.

There’s also a heavy emphasis on vehicle customization in the game, as the desert is vast and requires diverse transportation methods. This allows you to fuse different weaponry and components to improve performance or offer unique tactical advantages. However, your first vehicle will be a bare-bones golf cart, another nod to the source material.

Sand Land releases for PlayStation 5, PlayStation 4, Xbox Series X|S and PC, with pre-orders available now. There’s a number of different versions available for collectors. The Standard Edition includes just the base game, while the Deluxe Edition comes with various digital add-ons, along with decals. The Collector’s Edition comes with everything listed above, plus postcards and Steelbook packaging.

This article originally appeared on Engadget at https://www.engadget.com/sand-land-a-game-adaptation-of-akira-toriyamas-manga-drops-on-april-26-184008528.html?src=rss 

The US government has reportedly approved AI-based memory loss prediction software for the first time. Darmiyan, a San Francisco-based brain imaging analytics company, says the FDA has granted De Novo approval for its product BrainSee. The software platform assigns “an objective score that predicts the likelihood of progression from aMCI to Alzheimer’s dementia within 5 years,” according to the medical company. Fierce Biotech first reported the announcement.

Darmiyan says BrainSee can predict memory loss progression using clinical brain MRIs and cognitive tests, which are already standard for patients worried about early signs of decline. After the program analyzes the imaging and cognitive assessments, it assigns a predictive score indicating the patient’s odds of memory deterioration within the following five years. At least in theory, that would lead to early treatment for some and peace of mind for others.

“This shifts the patient experience from prolonged anxiety to proactive management, which is crucial in an era of emerging Alzheimer’s treatments where accurate prognosis can help determine suitable treatment candidates,” Darmiyan wrote in a press release announcing the FDA approval. “The economic impact of BrainSee will be significant for all stakeholders in healthcare, promising to reduce the billions of dollars annually spent on Alzheimer’s care, through more effective management and treatment.”

The FDA’s “De Novo” designation means the product has no clear market predecessors but has proven its effectiveness and safety in clinical trials. BrainSee first received FDA “breakthrough” designation in 2021, an earlier stage of the approval path for a first-of-its-kind treatment. 

Darmiyan says BrainSee is fully automated and provides results on the same day the scans and cognitive test scores are entered. The company views the tech as shifting the treatment of mild / early cognitive decline from biomarker-based methods to “non-invasive and actionable forecasts of future improvement or progression.”

This article originally appeared on Engadget at https://www.engadget.com/the-fda-has-reportedly-approved-an-ai-product-that-predicts-cognitive-decline-184534034.html?src=rss 

Want some bad news as a lead up to the weekend? NASA just released its annual global temperature report and, lo and behold, 2023 was the hottest year on record since measurements began back in 1880. Global temperatures last year were approximately 2.1 degrees Fahrenheit (1.2 degrees Celsius) above the average for NASA’s baseline period of 1951 to 1980.

Compared to the 1880s, the planet was 2.5 degrees warmer in 2023. If you do the math, you’ll find that the vast majority of that increase occurred after NASA’s baseline period. In other words, the past several decades have been the worst of the worst. July of 2023 was the hottest month ever measured, which is a record nobody wanted or asked for but, well, here we are.

“NASA and NOAA’s global temperature report confirms what billions of people around the world experienced last year; we are facing a climate crisis,” said NASA Administrator Bill Nelson. “From extreme heat, to wildfires, to rising sea levels, we can see our Earth is changing.”

NASA’s not burying its head in the sand and pretending this is a natural phenomenon. We did this, with Gavin Schmidt, director at the Goddard Institute for Space Studies (GISS), saying the temperature shift was primarily caused by “our fossil fuel emissions.”

2023 was not an outlier. The past ten consecutive years have been the warmest on record. To that end, the U.S. National Oceanic and Atmospheric Administration (NOAA) recently reported that 2024 has a one-in-three chance of being even hotter. Yay.

It’s also worth noting that 2023 featured some cooling events that actually worked to lower temperatures a bit, including volcanic aerosols in the atmosphere due to the January 2022 eruption of the Hunga Tonga-Hunga Ha’apai underwater volcano. However, these events couldn’t keep up with constant greenhouse gas emissions and the heating effects of this year’s El Niño weather event.

“We will continue to break records as long as greenhouse gas emissions keep going up,” Schmidt said. “And, unfortunately, we just set a new record for greenhouse gas emissions again this past year.”

The Biden-Harris administration has done a few things to try to slow down our transformation into a Mad Max dystopia. The White House recently launched the U.S. Greenhouse Gas Center to make critical climate data readily available and last year’s Inflation Reduction Act set aside $369 billion for climate and clean energy programs. President Biden has also pledged to bring emission levels to at least 50 percent below what we experienced in 2005 by 2025. These are good incremental moves, of that there’s no doubt, but we seem to have sped past “f*ck around” and are careening wildly into “find out.” What was that curse again? Oh yeah. May you live in interesting times.

This article originally appeared on Engadget at https://www.engadget.com/nasa-confirms-2023-was-the-hottest-year-on-record-193626460.html?src=rss