The FDA clears the first blood test for diagnosing Alzheimer’s disease

There’s a new way to screen for early detection of Alzheimer’s disease. On Friday, the Food and Drug Administration (FDA) cleared the first blood test for the disorder. Fujirebio Diagnostics’ Lumipulse measures the ratio of two proteins that correlate with the presence or absence of Alzheimer’s. Previously, patients being screened for Alzheimer’s were limited to more invasive options: a PET Scan or spinal tap.

Lumipulse is intended for use in clinical settings with patients exhibiting signs of cognitive decline. At least in its current form, it isn’t something the general population can ask for as a standard screening.

The test works by measuring two proteins: pTau217 and β-amyloid 1-42. The blood test calculates their ratio, which correlates with the buildup of amyloid plaques in the brain. People with Alzheimer’s have elevated pTau217 and lower β-amyloid 1-42.

In a clinical study, the test performed better with negative results than positive ones. As such, Reuters reports that the test will likely be used initially to rule out Alzheimer’s. Over 97 percent of negative results corresponded with a negative PET scan or CSF test result. Results for positives were a bit lower: a 91.7 percent correlation. So, positive results will need to be confirmed with more advanced diagnostic tests.

This article originally appeared on Engadget at https://www.engadget.com/science/the-fda-clears-the-first-blood-test-for-diagnosing-alzheimers-disease-201209676.html?src=rss 

Kojima is leaving behind a USB stick with game ideas for after he dies

Iconic video game maker Hideo Kojima has left behind a USB stick filled with game ideas in the case of his death, as indicated in an interview with Edge Magazine that VGC reported on. Kojima says it’s “kind of like a will” and that he hopes that his staff will continue to make games after he passes.

Don’t worry. He isn’t going anywhere anytime soon. This was spurred on by the pandemic. “Until then, I didn’t think I was old, you know? I just didn’t feel my age, and I assumed I would be able to create for as long as I live,” he told the magazine. Kojima is 61 years old, which is a spring chicken when compared to luminaries like Shigeru Miyamoto (72) and Sid Meier (71.)

Death Stranding 2 covers the next issue of EDGE Magazine with exclusive artwork from Yoji Shinkawa.

Releasing June 26th on PS5. pic.twitter.com/27bL9cZgHx

— KAMI (@Okami13_) May 15, 2025

While Kojima isn’t planning on leaving this mortal coil in the near future, he does say that he only has so much time left for active game development. He gives himself around ten years before he reaches an age in which his creative energy could be depleted.

So, the idea of a USB stick was born. He hopes it will allow Kojima Productions to carry on as an entity after he passes or retires. “This is a fear for me: what happens to Kojima Productions after I’m gone? I don’t want them to just manage our existing IP.”

While we don’t know what type of ideas are on the USB stick, Kojima did recently introduce a few off-the-wall game concepts regarding the passage of time. He discussed a concept involving memory, in which the main character gradually forgets important information and abilities if someone takes too long of a break from playing. Kojima also discussed a game that encompassed an entire life and another one that would involve the real-time creation of wine or cheese.

The designer also planned on a mechanic that made Sam’s beard grow over time in the forthcoming Death Stranding 2. However, he scrapped it because “Norman Reedus is a big star” and he didn’t “want to make him look uncool.”

This article originally appeared on Engadget at https://www.engadget.com/gaming/kojima-is-leaving-behind-a-usb-stick-with-game-ideas-for-after-he-dies-184029255.html?src=rss 

Ask Engadget: How do I answer calls on my iPhone with only my voice?

Last August, my best friend asked me how she could help her neighbor set her iPhone so she could answer it without picking it up. The neighbor had Multiple Sclerosis (MS), and had lost dexterity in both hands over time. Some Google searches revealed I was far from alone in my confusion. So I asked Apple for some advice. Here’s what I said:

Q: “My friend has advanced MS and has some (very little) control of one of her hands. She can’t really swipe a screen or tap buttons. She wants it so that when she receives a call, she can just ask Siri or tell her iPhone to answer or reject it. But based on my research, the only way that’s possible is if a user has AirPods or Apple Watch connected, so Siri can announce incoming calls and listen for commands like “Answer” or “Dismiss.”

I also looked in the accessibility settings for Voice Control and there’s a way to answer all incoming calls after a set amount of time. But due to privacy concerns and spam calls, that’s not an ideal solution.

I was wondering if you knew any way for incoming calls to be answered with a voice command?”

A: Apple did respond, but unfortunately the solution is… complicated. I’ll lay out the steps on how to use your iPhone with Voice Control first, since that does provide a somewhat effective workaround. But you should read past the steps for some of the caveats.

How to use Voice Control on iPhone to answer calls

Before we get started, make sure your phone is running iOS 13 or later. You can also use Voice Control on iPads or iPod Touch (if you still have one). When setting up Voice Control, make sure you’re connected to the internet to download the necessary files, and Apple recommends you connect to Wi-Fi before you turn on Voice Control to use it for the first time. When all that is done, proceed with the following steps.

Open the Settings app and find the Accessibility settings. This is in the second group of options just below “General.” You can also just search for “Accessibility.”

Select “Voice Control,” which is listed in the “Physical and motion” section.

Turn on Voice Control by tapping or sliding the toggle next to it, and, in some cases, wait for the download to finish. If you’ve enabled Voice Control before, you can also just ask Siri to “Turn on voice control.”

Once the feature is on, you’ll see little numbers floating around your screen, next to key elements. Your microphone is now on and your iPhone is listening for your commands.

Read out the number next to what you want to trigger. If you’ve been following this guide, you can say “one” to go back to the Accessibility settings menu.

Say “Show me what to say” for a detailed list of things you can do. You can use commands like “Swipe down” or “Move down” to scroll through pages. Just remember that “Swipe up” will scroll down and “Swipe down” will scroll up. The system will continue to recognize your touch inputs, too.

When a call comes in, read out the number next to the answer option. From the lock screen, that was the number “five” in my experience. When my phone was unlocked, the number to accept the call was “six,” while “five” would decline it.

Voice Control isn’t perfect

As you can see from that seventh step, Voice Control is complicated. You’ll need to be within view of your screen to see the labels, and saying the wrong number can cause you to hang up a call by accident. You can say “Show Names” to display words instead of numbers in the labels, but know that in this case you’ll need to add “Tap” before each label to press it. That means when a call comes in, you can say “Tap Answer” or the label corresponding to the action you want. 

I want to point out that the numerical labels don’t consistently appear in all apps (the search bar at the top of chats in WhatsApp, for example, doesn’t have a number attached to it in my experience). Occasionally, the names in the labels are also oddly chosen, like how the word attached to my widget for my self-care app was just “Image.” It also takes time to build familiarity with Voice Control and learn all the available actions. 

I also found the system to be sluggish, and it sometimes took a noticeable delay before a command like “Swipe left” was registered and carried out. On my first few attempts, I thought my iPhone didn’t hear me and repeated the instruction, only for it to swipe through two pages instead. I’m using an iPhone 16 Pro, which is Apple’s latest flagship, so it’s not like I’m on an older, slower device, either.

While we were able to achieve a semi-effective approach with the Voice Control workaround, it didn’t really solve my friend’s neighbor’s problem.

How to answer or decline calls with Siri

In researching this guide, I’ve found that either there is now a way to answer calls with Siri or there was always one that I had missed in August of 2024. Regardless, I was able to test it today in a few different scenarios and while it’s certainly more convenient, it’s not without its limitations. 

Go to Siri Settings in your phone. You can find this by searching for “Siri” in your Settings app or just scrolling till you see “Siri” or “Apple Intelligence & Siri.”

Make sure the setting to allow your iPhone to listen for “Siri” or “Hey Siri” is on. If you’re running the latest version of iOS on an iPhone 15 Pro, iPhone 16 or iPhone 16 Pro, this would be Talk & Type to Siri > “Hey Siri” or “Siri” or “Hey Siri” (whichever you prefer, as long as it’s not “Off”). On older iPhones or versions of iOS, it would be Talk to Siri > “Hey Siri” or “Siri” or “Hey Siri”

Turn on “Call Hang Up” if you want to be able to end a call with a voice command during the conversation. Otherwise, you’ll have to wait for the other party to hang up. Note: Call hang up only works on phone and FaceTime calls, not on those via third-party apps like WhatsApp or Telegram.

When a call comes in, say “Siri, answer” or “Hey Siri, answer” to accept. Say “Siri, decline the call” to reject it. In my testing, “Siri, decline” did not work, but “Siri, decline the call” did. 

I was able to use this method to answer calls not only through phone or FaceTime, but via third-party apps too. I enabled “Announce calls,” setting it to do so “Always” rather than only when headphones or CarPlay were connected. But I never saw or heard alerts when a call came, besides the actual ringing. When I asked my friend about using this method with their neighbor, they mentioned that her speech was so affected at that point that Siri wouldn’t always recognize what she was saying.

Accessibility in tech has improved, but needs to get even better

Sadly, that neighbor had passed away before we were able to resolve the issue. Though I wasn’t able to solve her problem, I’m putting the limited guidance I’ve been able to compile here in the hope that it might be useful to someone in a substantially similar situation. 

I have yet to properly test the offerings on Android, but on that platform there are settings for Voice Access to be enabled for incoming calls and to remain active during calls, indicating there are options to use voice commands there.

My friend’s neighbor’s challenges are shared by countless people who are still struggling with consumer technology tools that rarely meet their full needs — whether they’re temporary limitations from injuries or longterm issues resulting from disability or age. Voice-based interactions that are meant to help those with physical disabilities need to better recognize speech impediments at a wider level, and both Google and Apple, along with other major tech companies, have taken steps toward building better models in those respects. 

The memory of our frustration with voice control felt all the more timely this week, which marked the 14th annual Global Accessibility Awareness Day (the third Thursday of each May). We saw Apple and Google announce new accessibility features, while companies like Amazon, Netflix and Microsoft reminded us of the assistive tools they recently released. 

It’s heartening to see increased development in inclusively designed tech, but it’s also worth considering how complete and useful some of these “solutions” are. Many of us will either need some form of assistive technology at some point in our lives or know someone who does and would. In spite of the continued improvements, there’s still plenty to do to ensure tech is accessible to all.

This article originally appeared on Engadget at https://www.engadget.com/mobile/smartphones/ask-engadget-how-do-i-answer-calls-on-my-iphone-with-only-my-voice-193707009.html?src=rss 

Apple claims it’s not blocking Epic from offering Fortnite in the EU

After claiming that Apple was blocking Epic from offering Fortnite in both the US App Store and the Epic Games Store in the European Union, Apple now says it wasn’t, according to a report from Bloomberg.

A spokesperson told Bloomberg that Apple “did not take any action to remove the live version of Fortnite from alternative distribution marketplaces,” and that the company wants Epic’s European branch to resubmit the latest game update for publishing, “without including the US storefront of the App Store so as not to impact Fortnite in other geographies.”

Apple has blocked our Fortnite submission so we cannot release to the US App Store or to the Epic Games Store for iOS in the European Union. Now, sadly, Fortnite on iOS will be offline worldwide until Apple unblocks it.

— Fortnite (@Fortnite) May 16, 2025

While that sounds like a denial of wrongdoing, it does imply Apple specifically doesn’t want Epic to relaunch Fortnite on the US App Store. The company submitted Fortnite for publishing on May 9 following a victory in court that forced Apple to allow developers to support alternative payment methods for apps on the web. At the time, Epic CEO Tim Sweeney was hoping to use the change as justification to bring Fortnite back entirely, after only offering the game through streaming platforms on mobile.

Fortnite was originally removed from the App Store because Epic started directing players to circumvent Apple’s in-app payment system to buy in-game currency. The move was part of a larger plan from Epic to push back on Apple and Google’s tight control over their respective platforms and storefronts. That plan has partially worked. Thanks to Epic’s court win, multiple app developers are now offering alternative payment methods in their apps, but it obviously hasn’t changed how Apple feels about the game developer.

This article originally appeared on Engadget at https://www.engadget.com/apps/apple-claims-its-not-blocking-epic-from-offering-fortnite-in-the-eu-175423021.html?src=rss 

FCC approves Verizon’s $20 billion merger with Frontier

The FCC has announced its approval of the merger between communications giants Verizon and Frontier, after a deal was made last year. Verizon will acquire Frontier Communications for $9.6 billion in cash, in addition to absorbing $10 billion of debt.

Key to earning approval from the FCC was Verizon’s commitment to ending all DEI-related practices, in line with the Trump administration’s aim to dismantle all diversity, equity, and inclusion initiatives from both public organizations and private companies.

The statement from the FCC said the approval “ensures that discriminatory DEI policies end,” and that Verizon “has reaffirmed the merged entity’s commitment to equal opportunity and nondiscrimination.”

“By approving this deal, the FCC ensures that Americans will benefit from a series of good and commonsense wins. The transaction will unleash billions of dollars in new infrastructure builds in communities across the country—including rural America. This investment will accelerate the transition away from old, copper line networks to modern, high-speed ones. And it delivers for America’s tower and telecom crews who do the hard, often gritty work needed to build high-speed networks,” said Brendan Carr, FCC chairman.

Verizon plans to upgrade and expand Frontier’s existing network across 25 states and expects to deploy fiber to more than one million American homes annually.

This article originally appeared on Engadget at https://www.engadget.com/big-tech/fcc-approves-verizons-20-billion-merger-with-frontier-181434890.html?src=rss 

More Switch games are getting Switch 2 upgrades

More original Switch games are getting the Switch 2 treatment. Although their enhancements are subtler than the Switch 2 editions of Breath of the Wild and Tears of the Kingdom, at least these will be free updates.

On Friday, Nintendo detailed the legacy Switch titles that will receive upgrades for the Switch 2. They include some of the console’s best games from the company’s biggest franchises.

Most of the platform’s big Mario games are included: Super Mario Odyssey, Super Mario 3D World + Bowser’s Fury and New Super Mario Bros. U Deluxe. You’ll also find the platform’s top-down Zelda titles: Echoes of Wisdom and Link’s Awakening. A pair of Pokémon games makes the cut: Pokémon Scarlet and Pokémon Violet. Even Captain Toad’s Treasure Tracker gets in on the action.

The enhancements vary by title. They range from various visual upgrades to multiplayer GameShare functionality.

Here’s the complete list:

ARMS – visual upgrades (resolution, frame rates and HDR)  

Big Brain Academy: Brain vs. Brain – GameShare (up to four players, local / online GameChat sharing)  

Captain Toad: Treasure Tracker – visual upgrades (resolution and HDR) and GameShare (two players in all courses, local / online GameChat sharing)  

Clubhouse Games: 51 Worldwide Classics – GameShare (up to four players can play 34 games, local / online GameChat sharing)  

Game Builder Garage – visual upgrades (resolution), Joy-Con 2 mouse control  

New Super Mario Bros. U Deluxe – visual upgrades (resolution)  

Pokémon Scarlet – visual upgrades (resolution, frame rates)  

Pokémon Violet – visual upgrades (resolution, frame rates)  

Super Mario 3D World + Bowser’s Fury – visual upgrades (resolution, frame rates and HDR), GameShare (up to four players in Super Mario 3D World, two players in Bowser’s Fury and local / online GameChat sharing)  

Super Mario Odyssey – visual upgrades (resolution, frame rates), GameShare (two players, local / online GameChat sharing)  

The Legend of Zelda: Echoes of Wisdom – visual upgrades (resolution, HDR)  

The Legend of Zelda: Link’s Awakening – visual upgrades (resolution, HDR)

All of the free updates will be available on the Switch 2’s June 5 launch date. You’ll first need to install a system update for the new console.

This article originally appeared on Engadget at https://www.engadget.com/gaming/nintendo/more-switch-games-are-getting-switch-2-upgrades-182647659.html?src=rss 

Microsoft attemps to avoid EU fines by further decoupling Teams and Office

The European Commission (EC) has been firing on all cylinders in holding big tech to account through various fines and enforcement actions, attempting to create a more competitive landscape in a space that has become increasingly monopolized.

Microsoft has been in a years-long dispute with the EC, which opened an antitrust probe in 2023 after Slack filed a complaint in 2020 alleging that Microsoft’s bundling of Teams and Microsoft 365 was anticompetitive.

The company unbundled the two products in the EU shortly thereafter in a bid to avoid antitrust fines, but it wasn’t enough to appease the EC. In 2024, the Commission found that Microsoft did not go far enough and was still in violation of antitrust laws, risking massive fines.

This week, Microsoft responded with a more robust set of commitments. Its productivity software suites will continue to be offered without Teams in the European Economic Area (EEA) for at least seven years. Minimum price deltas will be set between versions of the suites that include Teams and those which do not.

Microsoft has also offered to align these options and pricing structures for its suites and Teams globally should the EC accept its proposal. Interoperability enhancements that make it easier to use third-party competitors to Teams were also included in the proposal.

“The proposed commitments are the result of constructive, good-faith discussions with the European Commission over several months. We believe that they represent a clear and complete resolution to the concerns raised by our competitors and will provide European customers with more choices,” said Nanna-Louise Linde, Microsoft’s VP of European Government Affairs.

The EC has begun an open feedback period, seeking comments from competitors and citizens on whether the proposed commitments by Microsoft are adequate and place the company back within the bounds of the EU’s antitrust regulations.

This article originally appeared on Engadget at https://www.engadget.com/big-tech/microsoft-attemps-to-avoid-eu-fines-by-further-decoupling-teams-and-office-170519085.html?src=rss 

Red Dead Redemption 2 could be coming to Switch 2 this year

Third-party support was a big theme of the Switch 2 reveal earlier this year, with many publishers seemingly keen to capitalize on both the popularity of the outgoing Switch and the significantly increased horsepower of its imminent successor. And if you’re looking to get third-party games on your new system, they don’t come much much bigger than Red Dead Redemption 2, which could be making its way to Nintendo’s new console later this year.

Gamereactor says it has heard from sources close to Rockstar (which it then corroborated with other sources) that the enormous open-world Western that first released in 2018 is bound for Switch 2, and could arrive either at the same time, or after, a long-rumored next-gen update for the PS5 and Xbox Series X. Red Dead Redemption 2 is of course currently playable on both of those platforms, but unlike GTA 5, it’s never been patched to support the higher frame rates and fidelity afforded by the newer hardware.

This should by no means be taken as an official announcement, but Rockstar has supported the current Switch pretty well throughout its life cycle, releasing ports of L.A. Noire, the original 3D Grand Theft Auto trilogy, and most recently the first Red Dead Redemption. If the Switch 2 can run its sequel, it’s a pretty safe bet to assume that Rockstar would want to do it, and the console is likely to be roughly equivalent in power to the base model PS4, according to Digital Foundry. It goes without saying that we’ll know a lot more about how the Switch 2 performs when the console is in the wild and put through its paces. 

Both a Nintendo Switch 2 port and current-gen patch for Red Dead Redemption 2 would be a good way for Rockstar to bridge the gap between now and the release of GTA 6, which was recently delayed until May 2026. With a 97 percent score on Metacritic, RDR2 is one of the developer’s most acclaimed titles to date, and you can be sure that a lot of people would happily hop back into the cowboy boots of Arthur Morgan while they wait to return to Vice City.

This article originally appeared on Engadget at https://www.engadget.com/gaming/red-dead-redemption-2-could-be-coming-to-switch-2-this-year-161043422.html?src=rss 

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