CRISPR can stop malaria spread by editing a single gene in mosquitos

CRISPR gene-editing therapy has shown great potential to treat and even cure diseases, but scientists are now discovering how it can be used to prevent them as well. A team of researchers found a way to edit a single gene in a mosquito that prevented it from transmitting malaria, according to a paper published in Nature. These genetically modified mosquitos could eventually be released into the wild, helping prevent some of the 600,000 malaria deaths that occur each year. 

Mosquitos infect up to 263 million people yearly with malaria and efforts to reduce their populations have stalled as late. That’s because both the mosquitos and their parasites that spread malaria have developed resistance to insecticides and other drugs. 

Now, biologists from UC San Diego, Johns Hopkins and UC Berkeley universities have figured out a way to stop malarial transmission by changing a single amino acid in mosquitos. The altered mosquitos can still bite people with malaria and pick up parasites from their blood, but those can no longer be spread to others. 

The system uses CRISPR-Cas9 “scissors” to cut out an unwanted amino acid (allele) that transmits malaria and replace it with a benign version. The undesirable allele, called L224, helps parasites swim to a mosquito’s salivary glands where they can then infect a person. The new amino acid, Q224, blocks two separate parasites from making it to the salivary glands, preventing infection in people or animals. 

“With a single, precise tweak, we’ve turned [a mosquito gene component] into a powerful shield that blocks multiple malaria parasite species and likely across diverse mosquito species and populations, paving the way for adaptable, real-world strategies to control this disease,” said researcher George Dimopoulos from Johns Hopkins University. 

Unlike previous methods of malarial control, changing that key gene doesn’t affect the health or reproduction capabilities of mosquitos. That allowed the researchers to create a technique for mosquito offspring to inherit the Q224 allele and spread it through their populations to stop malarial parasite transmission in its tracks. “We’ve harnessed nature’s own genetic tools to turn mosquitoes into allies against malaria,” Dimopoulos said. 

This article originally appeared on Engadget at https://www.engadget.com/science/crispr-can-stop-malaria-spread-by-editing-a-single-gene-in-mosquitos-133010031.html?src=rss 

Porsche 911 GTS review: The first hybrid 911 is better with a battery

When Porsche first unveiled the new 911 GTS, it’s safe to say that there weren’t many people on planet Earth pining for a hybrid 911. The idea of one of the world’s most iconic sports cars taking a cue from the humble Toyota Prius is a concept that’s a little hard for the average auto enthusiast to get their head around.

But they should try, because the technology that Porsche has deployed in the new 911 GTS, Porsche’s first hybrid sports car, is properly impressive. This is a hybrid system that exists not to improve fuel consumption, but to genuinely make a sports car better thanks to the injection of a little high voltage and a lot of boost.

Tech meets tradition

The 911 has maintained its stubborn rear-engined layout since the beginning. Its motor is slung between and behind the back wheels, not because it’s necessarily the best place for handling, but just because that’s how it’s always been done. That doesn’t change with the 911 GTS. What is new, though, is the addition of an electric motor into the mix, augmenting that gasoline engine in the way-back. That new motor sits neatly inside the eight-speed dual-clutch transmission, adding 54 horsepower and 29 pound-feet of torque.

Those numbers are hardly remarkable, but the real magic is what else the car does with its new high-voltage system. There’s actually a second electric motor here, a tiny one capable of surviving ridiculously hot temperatures. That’s needed because it lives within the turbocharger.

A turbocharger is a simple wheel that is spun by exhaust gas. This in turn spins another wheel that forces air into the engine’s intake. It’s a simple technology developed well over 100 years ago, but since those early days of forced induction, there’s always been an issue when it comes to automotive applications: lag. The reliance of exhaust gases to spin the turbocharger creates an intrinsic delay between the driver requesting acceleration and the car actually delivering it. Internal combustion needs to build pressure to spin the wheel to suck in more air to provide more power.

Porsche short-circuited that with this novel electric motor that spins the turbocharger up to 120,000 RPM in less than a second. Lag isn’t completely eliminated, but it’s so radically reduced that you hardly know it. Pair that with the extra, instant kick of torque provided by the electric motor in the transmission, and you have something magical: a car powered by gasoline that accelerates with all the instant ferocity of an EV.

Design sensibility

Tim Stevens for Engadget

Porsche calls that whole system, plus the 1.9-kWh battery that powers it, T-Hybrid. The net result in the 2025 911 GTS is 532 hp and 449 lb-ft of torque. That’s a substantial, 59-hp boost over the old GTS.

Yet the only obvious sign that there’s anything different about this car is the subtle T-Hybrid badges mounted down low on the doors. And that’s a good thing, because I’m of the opinion that the current-generation 911, internally called the 992.2, is one of the prettiest cars on the road. Even in this decidedly understated Chalk color, it is absolutely striking. The color pairs perfectly with the 20-inch front and 21-inch rear black wheels and other ebony highlights around the car.

The interior is similarly minimalist, monotone to an extreme. But there are just enough subtle highlights of materials like carbon fiber and Alcantara to make it feel racy and purposeful, not basic. And, if you like, you can go with many more wild interior combinations. Porsche is happy to let you customize to your heart’s content, but beware that it’s going to cost you.

The car’s interface is simpler than 911s of yore, too. Most of the controls have been consumed by the car’s petite 10.9-inch touchscreen, serving both wireless Android Auto and Apple CarPlay, while a curved, 12.6-inch virtual gauge cluster lives behind the steering wheel. What physical controls remain are well positioned, delivering strong tactility for your frequent tasks. Perhaps the most important is the drive mode dial that’s mounted at the four o’clock position on the steering wheel. It’s how you dial up the intensity of the 911 GTS. Or, push the shiny little red button to go fully manic.

Tim Stevens for Engadget

Driving

The GTS isn’t Porsche’s most powerful 911 of the moment. That honor lies in the 640-horsepower 911 Turbo S. But no other 911 delivers power like this one, offering a taste of the instant shove of the electric Taycan mixed with the internal combustion fury and high-speed acceleration you’d expect from a 911.

It is, suffice to say, quite intoxicating. And to get the best taste of it, push that aforementioned crimson button. That gives you 20 seconds of Sport Response mode, with the car’s electronic turbocharger assist doing its damndest to maintain maximum power. The exhaust opens fully, the transmission drops a gear or two and suddenly that machine you were idling through traffic absolutely comes alive.

Put your foot down in this mode and the 911 GTS surges forward, without a moment’s hesitation. You can hear the turbocharger behind your head whistling as it works to build intake pressure, hauling in air from the environment and jamming it right into the combustion chamber for the next squeeze and bang.It’s addictive, but if you’ve become used to the silent surging power of an EV, it’s perhaps a bit much. In Sport Mode, the standard sport exhaust on the GTS is loud enough to terrify anyone you go soaring past on a two-lane road.

Thankfully, the GTS is easy to silence. One tap of the exhaust button mounted below that touchscreen and the GTS becomes quiet. It’s not-quite EV quiet, but very hushed. Despite having electric motors and a battery, this is not a plug-in hybrid. You’ll struggle to even get out of your driveway without that engine firing up. But that’s okay. Remember: This isn’t an efficiency play.

In Normal mode, the suspension softens and the ultra-fast transmission transitions into something that smoothly slips from one gear to the next, keeping revs as low as possible to maximize fuel consumption. That nets the 911 GTS a 19 mpg combined rating per the EPA. Despite some bits of driving exuberance, I substantially bettered that, managing 25.1 mpg.

Tim Stevens for Engadget

But even at its most tame, the GTS is not a luxury grand tourer of the likes of an Aston Martin DB12 or Mercedes-AMG GT. At its softest, the suspension is still firm, the road noise from those prodigious tires is grating and even the wind noise at high speed is a bother — so much so that the middling Bose sound system struggles to overcome it.

So, despite the GTS moniker, it’s more of a sports car than a grand tourer. Instant power is this car’s party trick, paired with amazing feel, effortless handling and the kind of prodigious grip that will make your favorite driving roads feel tame.

Those are all the more reasons to find your new favorite roads. Despite punishing you on the highway and over broken asphalt, the 911 GTS never feels flustered and always leaves you wanting more. It’s a car you won’t want to get out of, which perhaps explains why I’m writing this very sentence from the driver’s seat.

Cost of entry

At over $170,000 to start, or $196,185 as configured, it’s not an affordable machine. Were I buying, my GTS would be a little cheaper. I’d stick with the rear-drive GTS model, rather than the all-wheel drive Carrera 4 you see here, simply for the fun-factor. I’d also skip the sunroof, which adds both $2,980 to the bill and weight to a car that already gained over 100 pounds compared to the prior GTS.

Those two deletions alone would cut about $10,000 from that still-soaring price. Expensive, yes, but the technology here feels worth it. This is a novel approach to electrification, making a sports car sportier with hardly any compromise. It is a truly desirable machine, the kind of hybrid that Porsche fans may not have known they needed, but one they definitely need to try.

This article originally appeared on Engadget at https://www.engadget.com/transportation/porsche-911-gts-review-the-first-hybrid-911-is-better-with-a-battery-120038613.html?src=rss 

Internet Archive is now an official US government document library

The US Senate has granted the Internet Archive federal depository status, making it officially part of an 1,100-library network that gives the public access to government documents, KQED reported. The designation was made official in a letter from California Senator Alex Padilla to the Government Publishing Office that oversees the network. “The Archive’s digital-first approach makes it the perfect fit for a modern federal depository library, expanding access to federal government publications amid an increasingly digital landscape,” he wrote. 

Established by Congress in 1813, the Federal Depository Library Program is designed to help the public access government records. Each congressional member can designate up to two libraries, which include government information like budgets, a code of federal regulations, presidential documents, economic reports and census data. 

With its new status, the Internet Archive will be gain improved access to government materials, founder Brewster Kahle said in a statement. “By being part of the program itself, it just gets us closer to the source of where the materials are coming from, so that it’s more reliably delivered to the Internet Archive, to then be made available to the patrons of the Internet Archive or partner libraries.” The Archive could also help other libraries move toward digital preservation, given its experience in that area. 

It’s some good news for the site which has faced legal battles of late. It was sued by major publishers over loans of digital books during the Coronavirus epidemic and was forced by a federal court in 2023 to remove more than half a million titles. And more recently, major music label filed lawsuits over its Great 78 Project that strove to preserve 78 RPM records. If it loses that case it could owe more than $700 million damages and possibly be forced to shut down. 

The new designation likely won’t aid its legal problems, but it does affirm the site’s importance to the public. “In October, the Internet Archive will hit a milestone of 1 trillion pages,” Kahle wrote. “And that 1 trillion is not just a testament to what libraries are able to do, but actually the sharing that people and governments have to try and create an educated populace.”

This article originally appeared on Engadget at https://www.engadget.com/general/internet-archive-is-now-an-official-us-government-document-library-123036065.html?src=rss 

The Morning After: Apple’s iOS 26 beta is ready for the public

A few months since WWDC 2025, and Apple is shifting its OS update from developers to brave members of the public. Yesterday, the company launched the public beta version of all its operating systems, now all under the umbrella of “26”, making my job a little bit easier.

I’ve been testing the iOS 26 beta, which (like the rest) centers on a major design shift to Liquid Glass, with transparent overlapping elements and fluid animations. While it looks different, Apple’s focus seems to be familiarity and guiding the user in how to use its hardware, across mobile, PC and the rest.

Engadget

In iOS 26 specifically, key updates include a relocated search bar, improved Visual Intelligence for screenshots and boosted performance across many Apple Intelligence features, like voice note transcription, Genmoji and Image Playground (even if it thinks I’m entirely bald).

The Camera app has been redesigned, Apple Music gains AutoMix and Messages offers more engaging options, with custom backgrounds and live translation. However, while the update focuses heavily on design and system consistency, new Siri enhancements aren’t here yet.

Check out the full previews on the beta builds of iOS 26 here, macOS 26 here and iPadOS here.

— Mat Smith

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Maingear’s new PC is beige ’90s desktop meets raytracing

Back when the Millennium bug was the scariest thing out there.

Maingear

Maingear’s Retro95 is a new custom desktop PC that blends the aesthetic of ’90s beige desktops with modern, high-performance components. While its exterior evokes a 30-year-old machine that introduced many of us to dial-up internet, the Retro95 can be equipped with powerful internals, such as NVIDIA GeForce RTX 5080 graphics and the latest processors from Intel and AMD.

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These smartphone cases give any iPhone a USB-C port

Bring that iPhone X up to date!

Ken Pillonel

After creating the first ever (unofficial) USB-C iPhone back in 2021, Ken Pillonel has created an iPhone case that can give older device models a USB-C port, welcoming them to 2025. You can browse the options in his shop. The cases cover all 20 iPhones with Lightning ports and support data transfer.

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Anker Nebula X1 projector review

The king of outdoor movies, if you can afford it.

Engadget

The Nebula X1 is an odd proposition. While Anker has produced multiple projectors in the past, it has never reached the $3,000 mark. For that money, though, it beams out a category-leading 3,500 ANSI lumens at 4K resolution. It also features never-before-seen innovations in home projectors, including liquid cooling to reduce fan noise and a motorized lens gimbal that automates setup.

It’s framed as a portable outdoor projector, but it’s also just one of the best indoor projectors we’ve ever tested. With a sharp, high-contrast and color-accurate image, the video quality is stellar. It’s also easy to set up and incredibly versatile.

Continue reading.

This article originally appeared on Engadget at https://www.engadget.com/general/the-morning-after-engadget-newsletter-111549934.html?src=rss 

FCC approves Skydance’s $8 billion Paramount acquisition

Regulators won’t stand in the way of Skydance’s Paramount acquisition. The Federal Communications Commission has approved the $8 billion purchase of Paramount Global and its subsidiaries, including the parent company of CBS Network. In a statement, FCC Chairman Brendan Carr said he welcomes “Skydance’s commitment to make significant changes at the once storied CBS broadcast network.” Skydance, he said, has made written commitments to ensure that its “news and entertainment programming will embody a diversity of viewpoints across the political and ideological spectrum.” He also said that Skydance has “committed that it will not establish” DEI programs.

“Americans no longer trust the legacy national news media to report fully, accurately, and fairly. It is time for a change…These commitments, if implemented, would enable CBS to operate in the public interest and focus on fair, unbiased, and fact-based coverage. Doing so would begin the process of earning back Americans’ trust. Today’s decision also marks another step forward in the FCC’s efforts to eliminate invidious forms of DEI discrimination,” part of Carr’s statement reads. 

FCC Commissioner Anna M. Gomez, however, issued a statement saying she cannot support the deal “in light of the payout and other troubling concessions Paramount made to settle a baseless lawsuit.” In early July, Paramount agreed to pay $16 million to settle the lawsuit Donald Trump filed over a CBS interview with Kamala Harris during the 2020 presidential campaign. His lawyers accused the network of editing her answers to “confuse, deceive and mislead the public.” 

Legal experts said at the time that Paramount may have settled to ensure that there are no obstacles for the merger’s approval. When news about the acquisition first came out, the company said that it plans to rebuild its streaming technology while reducing costs under its new CEO David Ellison. Paramount, after all, invested billions into its streaming service Paramount+, and it had yet to turn a profit. The company said that it was allocating the $16 million to Trump’s future presidential library and not paying him “directly or indirectly.”

“In an unprecedented move, this once-independent FCC used its vast power to pressure Paramount to broker a private legal settlement and further erode press freedom,” Gomez said in her statement. “Once again, the agency is undermining legitimate efforts to combat discrimination and expand opportunity by overstepping its authority and intervening in employment matters reserved for other government entities with proper jurisdiction on these issues. Even more alarming, it is now imposing never-before-seen controls over newsroom decisions and editorial judgment, in direct violation of the First Amendment and the law.”

She added: “The Paramount payout and this reckless approval have emboldened those who believe the government can — and should — abuse its power to extract financial and ideological concessions, demand favored treatment, and secure positive media coverage. It is a dark chapter in a long and growing record of abuse that threatens press freedom in this country. But such violations endure only when institutions choose capitulation over courage. It is time for companies, journalists, and citizens alike to stand up and speak out, because unchecked and unquestioned power has no rightful place in America.”

This article originally appeared on Engadget at https://www.engadget.com/entertainment/fcc-approves-skydances-8-billion-paramount-acquisition-032028104.html?src=rss 

Intel confirms it will cut a third of its workforce by the end of 2025

Intel provided more detail about the scope of its planned job cuts and other business changes while sharing its second-quarter earnings results. Reports in April suggested that Intel could eliminate around 20 percent of its staff in a restructuring plan. Today, the chipmaker said it anticipates having a core workforce of 75,000 employees by the end of 2025. That’s about a third less than the 108,900 people it employed at the close of the previous fiscal year.

These cuts are part of the company’s current goal to bring its non-GAAP operating expenses down to $17 billion this year, then to $16 billion at the end of 2026. The effort to rein in spending is also leading Intel to abandon some previously announced expansions. The business will no longer embark on new projects in Germany and Poland, and it said it will consolidate its Costa Rican testing and assembly operations into existing efforts in Vietnam and Malaysia. Finally, it will also “slow the pace” of its stateside growth at a construction site in Ohio.

“Our operating performance demonstrates the initial progress we are making to improve our execution and drive greater efficiency,” said Lip-Bu Tan, who has been forthright about his plans to downsize since assuming the CEO title in March. Tan was brought in to replace Pat Gelsinger in an effort to turn around Intel’s business following a long, slow slide into financial trouble.

This article originally appeared on Engadget at https://www.engadget.com/big-tech/intel-confirms-it-will-cut-a-third-of-its-workforce-by-the-end-of-2025-215014365.html?src=rss 

Starlink is experiencing a network outage

SpaceX’s Starlink satellite internet service is experiencing an outage. Reports of connectivity issues started around 3:20PM ET, based on DownDetector. SpaceX didn’t acknowledged the outage until 4:05PM ET, via a post on the Starlink X account. As of 5:30PM ET, the service is still down.

The outage appears to be global. Users across the US, Europe, the UK and Asia have all reported issues on r/starlink, the service’s Reddit page, and SpaceX has even acknowledged the outage on Starlink’s website. The number of people potentially impacted could number in the millions — as of the last network update, there’s over six million active Starlink customers globally.

“Starlink is currently in a network outage and we are actively implementing a solution,” SpaceX shared in an X post. “We appreciate your patience, we’ll share an update once this issue is resolved.”

Starlink is currently in a network outage and we are actively implementing a solution. We appreciate your patience, we’ll share an update once this issue is resolved.

— Starlink (@Starlink) July 24, 2025

Starlink is designed to be accessible where traditional service providers can’t reach, making it a common option for van lifers and anyone living without traditional internet infrastructure. SpaceX has also partnered with companies like T-Mobile to use Starlink to extend smartphone connectivity outside the bounds of traditional cell networks. It’s not clear how T-Mobile’s Starlink service has been impacted as by the outage.

Developing…

This article originally appeared on Engadget at https://www.engadget.com/science/space/starlink-is-experiencing-a-network-outage-204002103.html?src=rss 

True Gambling Stories That Gave Life to Hollywood’s Casino Films

Hunter S. Thompson once said, “Without gambling, I would not exist.” Well, neither would some of our favorite blockbuster movies. It may interest you to know that some top Hollywood movies are based on true-life casino tales. However, beyond the lights, camera, and action, some of these movies thoroughly capture actual gambling events. In this…

Hunter S. Thompson once said, “Without gambling, I would not exist.” Well, neither would some of our favorite blockbuster movies. It may interest you to know that some top Hollywood movies are based on true-life casino tales. However, beyond the lights, camera, and action, some of these movies thoroughly capture actual gambling events. In this… 

Google will use AI to organize search results with Web Guide

Google’s latest AI adventure is a new option for search. Web Guide is a new way that Google will organize search results based on analysis by a dedicated version of its Gemini artificial intelligence tool. The claim in the announcement is that AI can help surface the most relevant content, but it could also be a new way for Google to control what websites get prime billing in results. 

In the graphic shared alongside the blog post announcing this Search Labs experiment, the company showed clusters of results to the query “how to solo travel in Japan.” Web Guide displayed a few hits each under different headers, such as “Comprehensive Guides for Solo Travel in Japan,” “Personal Experiences and Tips from Solo Travelers” and “Safety and Destination Recommendations,” with an option to reveal more for each grouping. It does seem to provide some AI-generated summaries at the top of each heading, but at least with this example, there are fewer instances of copy/pasting another publication’s words wholesale.

Web Guide has some similarities to Google’s AI Mode, which looped artificial intelligence more tightly into the search experience. The presence of AI Mode for all US users has already prompted outcry from publishers; News/Media Alliance called it “theft.” Pew Research Center recently issued a report confirming that the presence of an AI summary at the top of a search led to fewer people clicking through to read published content from a source. The group’s survey of 900 adults who shared their browsing history revealed that for users who did not see an AI summary, 15 percent of them clicked on a link from search results and 16 percent ended their browsing session. In contract, only 8 percent of users who saw an AI summary clicked a link in the search results, and 26 percent ended their browsing session. And while Google has been working to improve their accuracy, let us never forget that those AI-penned summaries once gave us glue pizza.

It’s too early to know if Web Guide will encourage more people to actually visit and support sites other than Google. For now, it’s only available for opted-in users in the Web tab for search, but it will appear elsewhere down the line. Given that Google is already in the legal dog house for anticompetitive behavior with its search business, it should be interesting to see how this latest AI rollout goes.

This article originally appeared on Engadget at https://www.engadget.com/ai/google-will-use-ai-to-organize-search-results-with-web-guide-191135024.html?src=rss 

The Pixel Watch 4 might charge via a wireless charging stand

The Pixel Watch 4 could use an entirely different charging system when its officially announced in a few weeks, according to leaked renders from Android Headlines. Rather than charging through fiddly pogo pins like past Pixel Watches, the renders suggest Google might finally adopt a simpler form of wireless charging.

The renders show the new Pixel Watch charging in a stand on its side, while displaying the current charge, the time and an upcoming alarm, not unlike an Apple Watch. The stand reportedly powers up the smartwatch through conductive metal contacts on the left side, opposite the Pixel Watch 4’s crown. The new charging contacts were visible in an earlier leak of the Pixel Watch 4, which also suggested the new smartwatch could be thicker than the Pixel Watch 3.

Android Headlines

Android Headlines reports that Google’s decision to change how the watch charges could unlock several new benefits. The Pixel Watch 4 will reportedly have a “25 percent faster charging speed,” room for new sensors and a design that’s easier to repair than past Pixel Watches, thanks to a removable back plate.

The new watch is also rumored to feature a brighter display and come in new colors. You can buy the Pixel Watch 3 in Polished Silver, Champagne Gold or Matte Black, in both 41mm and 45mm sizes. The Pixel Watch 4 will reportedly come in black, silver, gold and a blueish-gray “Moonstone.”

Google is expected to debut the Pixel Watch 4 alongside several new Pixel 10 phones on August 20. You can read Engadget’s preview of what Google might announce for an overview of what to expect at the event.

This article originally appeared on Engadget at https://www.engadget.com/wearables/the-pixel-watch-4-might-charge-via-a-wireless-charging-stand-193621297.html?src=rss 

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